Cryoballoon atrial fibrillation ablation: Single-center safety and efficacy data using a novel cryoballoon technology compared to a historical balloon platform.

Autor: Kochi AN; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy.; Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil., Moltrasio M; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Tundo F; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Riva S; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Ascione C; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Dessanai MA; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Pizzamiglio F; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Vettor G; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Cellucci S; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Gasperetti A; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy., Tondo C; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy.; Department of Biochemical, Surgical and Dentist Sciences, University of Milan, Milan, Italy., Fassini G; Heart Rhythm Center at Centro Cardiologico Monzino IRCCS, Milan, Italy.
Jazyk: angličtina
Zdroj: Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2021 Mar; Vol. 32 (3), pp. 588-594. Date of Electronic Publication: 2021 Feb 10.
DOI: 10.1111/jce.14930
Abstrakt: Introduction: Catheter ablation is superior to drugs regarding atrial fibrillation (AF) recurrence, symptoms improvement, and mortality reduction in heart failure. POLARx™ is a novel cryoballoon, with technical improvements seeking to improve outcomes. So far, its clinical evidence is restricted to a case report.
Methods: To compare the POLARx™ cryoballoon procedural safety and efficacy to the already established Arctic Front Advance PRO™ (AFAP) in a single-center cohort study, consecutive patients undergoing AF cryoablation with the POLARx™ were enrolled. Data were prospectively gathered. POLARx™ patients were compared with a historical cohort of patients submitted to AF cryoablation with the AFAP.
Results: Seventy patients were analyzed, 20 in POLARx™, and 50 in the AFAP group. They all underwent first-time pulmonary vein isolation, 77% were male, 94% had paroxysmal AF, median age was 62.5 years, median CHA 2 DS 2 -VASc 1, left-atrium size 34 ml/m², and 65% were receiving anticoagulation. The primary end-point, all pulmonary veins isolation, was 100% in both groups. The complication rate was similar (0% POLARx™ vs. 5.7% AFAP, p = .39). The median total procedural time was longer in the POLARx™ group (90 min vs. 60 min, p < .001), but the overall time-to-isolation (TTI; 44.8 s vs. 39 s, p = .253) and ablation time (15 min vs. 13.7 min, p = .122) was similar between POLARx™ and AFAP groups, respectively. Despite equal TTI, the POLARx™ had a lower minimal temperature reached (-57°C vs -47°C, p < .001).
Conclusion: The novel POLARx™ cryoballoon had similar efficacy and safety compared with the AFAP. It was also associated with longer procedural times, similar TTI, and lower minimum temperature reached.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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