Transient receptor potential channels in sensory mechanisms of the lower urinary tract.

Autor: Vanneste M; Laboratory of Ion Channel Research, VIB Center for Brain & Disease Research, Leuven, and Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Segal A; Laboratory of Ion Channel Research, VIB Center for Brain & Disease Research, Leuven, and Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Voets T; Laboratory of Ion Channel Research, VIB Center for Brain & Disease Research, Leuven, and Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Everaerts W; Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. wouter.everaerts@kuleuven.be.
Jazyk: angličtina
Zdroj: Nature reviews. Urology [Nat Rev Urol] 2021 Mar; Vol. 18 (3), pp. 139-159. Date of Electronic Publication: 2021 Feb 03.
DOI: 10.1038/s41585-021-00428-6
Abstrakt: Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has stimulated research into the molecular mechanisms that underlie neuronal control of the bladder and transient receptor potential (TRP) channels have emerged as key regulators of the sensory processes that regulate bladder function. TRP channels function as molecular sensors in urothelial cells and afferent nerve fibres and can be considered the origin of bladder sensations. TRP channels in the lower urinary tract contribute to the generation of normal and abnormal bladder sensations through a variety of mechanisms, and have demonstrated potential as targets for the treatment of LUTS in functional disorders of the lower urinary tract.
Databáze: MEDLINE
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