Characterization of Optimized TiO 2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance.

Autor: Nogueira RP; Chemical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates.; Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, GrenobleINPLEPMI, Grenoble 38000, France., Deuzimar Uchoa J; Federal Institute of Education, Science and Technology of Piauí, Teresina 64053-390, Brazil.; Interdisciplinary Laboratory for Advanced Materials, BioMatLab Group, Materials Science and Engineering Graduate Program, UFPI - Federal University of Piaui, Teresina 64049-550 Brazil., Hilario F; Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, GrenobleINPLEPMI, Grenoble 38000, France., Santana-Melo GF; Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Sao Paulo State University, Sao José dos Campos 12245-000, Brazil., de Vasconcellos LMR; Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Sao Paulo State University, Sao José dos Campos 12245-000, Brazil., Marciano FR; Department of Physics, Federal University of Piaui, Teresina PI 64049-550 Brazil., Roche V; Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, GrenobleINPLEPMI, Grenoble 38000, France., Moreira Jorge Junior A; Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, GrenobleINPLEPMI, Grenoble 38000, France.; Department of Materials Engineering, Federal University of São Carlos, São Carlos 13565-905, Brazil., Lobo AO; Interdisciplinary Laboratory for Advanced Materials, BioMatLab Group, Materials Science and Engineering Graduate Program, UFPI - Federal University of Piaui, Teresina 64049-550 Brazil.
Jazyk: angličtina
Zdroj: International journal of nanomedicine [Int J Nanomedicine] 2021 Jan 26; Vol. 16, pp. 667-682. Date of Electronic Publication: 2021 Jan 26 (Print Publication: 2021).
DOI: 10.2147/IJN.S285805
Abstrakt: Background: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants.
Methods: The study's main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO 2 nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte. Layers of small-short and large-long nanotubes were prepared and investigated in their amorphous and crystallized states and compared to non-anodized samples.
Results: Results show that much more than the surface area development associated with the nanotubes' growth; it is the heat treatment-induced change from amorphous to crystalline anatase-rutile structures that ensure enhanced biological activity coupled to high corrosion resistance.
Conclusion: Compared to both non-anodized and amorphous nanotubes layers, the crystallized nano-structures' outstanding bioactivity was related to the remarkable increase in their hydrophilic behavior, while the enhanced electrochemical stability was ascribed to the thickening of the dense rutile barrier layer at the Ti surface beneath the nanotubes.
Competing Interests: The authors report no conflicts of interest related to this work.
(© 2021 Nogueira et al.)
Databáze: MEDLINE
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