The power of the force: mechano-physiology of the giant titin.
| Autor: | Rivas-Pardo JA; Department of Physics, Universidad de Santiago de Chile, Ecuador, Santiago 3493, Chile.; Department of Biology, Universidad de Santiago de Chile, Alameda, Santiago 3363, Chile. |
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| Jazyk: | angličtina |
| Zdroj: | Emerging topics in life sciences [Emerg Top Life Sci] 2018 Dec 21; Vol. 2 (5), pp. 681-686. |
| DOI: | 10.1042/ETLS20180046 |
| Abstrakt: | Titin - the largest protein in the human body - spans half of the muscle sarcomere from the Z-disk to the M-band through a single polypeptide chain. More than 30 000 amino acid residues coded from a single gene (TTN, in humans Q8WZ42) form a long filamentous protein organized in individual globular domains concatenated in tandem. Owing to its location and close interaction with the other muscle filaments, titin is considered the third filament of muscle, after the thick-myosin and the thin-actin filaments. (© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology.) |
| Databáze: | MEDLINE |
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