Transcriptomic Signatures and Upstream Regulation in Human Skeletal Muscle Adapted to Disuse and Aerobic Exercise.

Autor: Makhnovskii PA; Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia., Bokov RO; Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia., Kolpakov FA; Institute of Computational Technologies of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Popov DV; Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.; Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 26; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 26.
DOI: 10.3390/ijms22031208
Abstrakt: Inactivity is associated with the development of numerous disorders. Regular aerobic exercise is broadly used as a key intervention to prevent and treat these pathological conditions. In our meta-analysis we aimed to identify and compare (i) the transcriptomic signatures related to disuse, regular and acute aerobic exercise in human skeletal muscle and (ii) the biological effects and transcription factors associated with these transcriptomic changes. A standardized workflow with robust cut-off criteria was used to analyze 27 transcriptomic datasets for the vastus lateralis muscle of healthy humans subjected to disuse, regular and acute aerobic exercise. We evaluated the role of transcriptional regulation in the phenotypic changes described in the literature. The responses to chronic interventions (disuse and regular training) partially correspond to the phenotypic effects. Acute exercise induces changes that are mainly related to the regulation of gene expression, including a strong enrichment of several transcription factors (most of which are related to the ATF/CREB/AP-1 superfamily) and a massive increase in the expression levels of genes encoding transcription factors and co-activators. Overall, the adaptation strategies of skeletal muscle to decreased and increased levels of physical activity differ in direction and demonstrate qualitative differences that are closely associated with the activation of different sets of transcription factors.
Databáze: MEDLINE
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