Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center.

Autor:	Bashiri FA; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Al-Sehemi MA; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Hamad MH; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Alshammari NR; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Aljumah MA; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Kentab A; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia., Salih MA; From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Neurosciences (Riyadh, Saudi Arabia) [Neurosciences (Riyadh)] 2021 Jan; Vol. 26 (1), pp. 21-25.
DOI:	10.17712/nsj.2021.1.20200087
Abstrakt:	Objectives: To assess the neurodevelopmental and epilepsy outcomes in children with infantile spasms (IS). Methods: A retrospective chart review of all patients with infantile spasms admitted to King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia between January 2000 and December 2017. Infants who were diagnosed to have IS as per the International League Against Epilepsy (ILAE) definition were included in this study. Patients who lost follow-up and those who did not receive treatment at KKUH were excluded. Results: Total of 53 patients were included and categorized into unknown, cryptogenic and symptomatic type of IS. The majority had symptomatic etiology (71.7%). Type of etiology and delay in initiation of treatment were significant predictors of motor and cognitive outcomes, but not seizure control. Patients with unknown IS, who were diagnosed earlier (0.72-month), had better neurodevelopmental outcomes. Vigabatrin in combination with either Adrenocorticotropic hormone (ACTH) or Prednisolone showed better seizure control in comparison to monotherapy and other combination modalities. Conclusion: Neurodevelopmental outcomes of IS are strongly associated with the underlying etiology. Early initiation of treatments had a favorable cognitive and motor outcome. Early response to combination therapy with resolution of spasms and hypsarrhythmia had better seizure outcomes. However, motor and cognitive outcomes were not affected by the response to the combination therapy. (Copyright: © Neurosciences.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu