Alternating sources of perisomatic inhibition during behavior.

Autor:	Dudok B; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: bdudok@stanford.edu., Klein PM; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Hwaun E; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Lee BR; Allen Institute for Brain Science, Seattle, WA 98109, USA., Yao Z; Allen Institute for Brain Science, Seattle, WA 98109, USA., Fong O; Allen Institute for Brain Science, Seattle, WA 98109, USA., Bowler JC; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Terada S; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Sparks FT; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Szabo GG; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Farrell JS; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Berg J; Allen Institute for Brain Science, Seattle, WA 98109, USA., Daigle TL; Allen Institute for Brain Science, Seattle, WA 98109, USA., Tasic B; Allen Institute for Brain Science, Seattle, WA 98109, USA., Dimidschstein J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fishell G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA., Losonczy A; Department of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Zeng H; Allen Institute for Brain Science, Seattle, WA 98109, USA., Soltesz I; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2021 Mar 17; Vol. 109 (6), pp. 997-1012.e9. Date of Electronic Publication: 2021 Feb 01.
DOI:	10.1016/j.neuron.2021.01.003
Abstrakt:	Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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