Clinical and whole genome characterization of SARS-CoV-2 in India.

Autor: Muttineni R; Virus Research Laboratory, Department of Zoology, Osmania University, Hyderabad, India., Kammili N; Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad, India., Bingi TC; Department of General Medicine, Gandhi Medical College and Hospital, Secunderabad, India., Rao M R; Department of General Medicine, Gandhi Medical College and Hospital, Secunderabad, India., Putty K; Department of Veterinary Biotechnology, College of Veterinary Science, Rajendranagar, PVNR Telangana Veterinary University, Hyderabad, India., Dholaniya PS; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India., Puli RK; Telangana State Council for Science and Technology, Government of Telangana, Hyderabad, India., Pakalapati S; Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad, India., S S; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India., K S; Virus Research Laboratory, Department of Zoology, Osmania University, Hyderabad, India., Doodipala MR; Department of Mathematics, GITAM University, Hyderabad, India., Upadhyay AA; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States of America., Bosinger SE; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States of America., Amara RR; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States of America., Kondapi AK; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Feb 02; Vol. 16 (2), pp. e0246173. Date of Electronic Publication: 2021 Feb 02 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0246173
Abstrakt: We report clinical profile of hundred and nine patients with SARS CoV-2 infection, and whole genome sequences (WGS) of seven virus isolates from the first reported cases in India, with various international travel histories. Comorbidities such as diabetes, hypertension, and cardiovascular disease were frequently associated with severity of the disease. WBC and neutrophil counts showed an increase, while lymphocyte counts decreased in patients with severe infection suggesting a possible neutrophil mediated organ damage, while immune activity may be diminished with decrease in lymphocytes leading to disease severity. Increase in SGOT, SGPT and blood urea suggests the functional deficiencies of liver, heart, and kidney in patients who succumbed to the disease when compared to the group of recovered patients. The WGS analysis showed that these isolates were classified into two clades: I/A3i, and A2a (four according to GISAID: O, L, GR, and GH). Further, WGS phylogeny and travel history together indicate possible transmission from Middle East and Europe. Three S protein variants: Wuhan reference, D614G, and Y28H were identified predicted to possess different binding affinities to host ACE2.
Competing Interests: The authors have declared that no competing interests
Databáze: MEDLINE
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