A Cluster of Neonatal Infections Caused by Candida auris at a Large Referral Center in Colombia.

Autor: Alvarado-Socarras JL; Fundación Cardiovascular de Colombia, Bucaramanga, Colombia., Vargas-Soler JA; Fundación Cardiovascular de Colombia, Bucaramanga, Colombia., Franco-Paredes C; Anschutz Medical Center, University of Colorado, Aurora, Colorado, USA.; Hospital Infantil de México Federico Gomez, México City, México., Villegas-Lamus KC; Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia., Rojas-Torres JP; Fundación Cardiovascular de Colombia, Bucaramanga, Colombia., Rodriguez-Morales AJ; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia.; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Americas, Pereira, Colombia.; Universidad Privada Franz Tamayo (UNIFRANZ), Cochabamba, Bolivia.
Jazyk: angličtina
Zdroj: Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2021 May 28; Vol. 10 (5), pp. 549-555.
DOI: 10.1093/jpids/piaa152
Abstrakt: Background: Globally, Candida auris is an emerging pathogen that poses an essential threat in healthcare settings presenting as outbreaks requiring significant allocation of infection control interventions to curb transmission. This fungal pathogen was initially identified in 2009 in Japan, but it has spread to all continents. Candida auris poses significant diagnostic and treatment challenges. Conventional microbiology laboratories often misidentify this pathogen as Candida haemulonii or as other Candida spp., Rhodoturola glutinis, and even with some bacterial pathogens, including Neisseria meningitidis serogroup A. Furthermore, C. auris displays distinct mechanisms of antifungal resistance to azoles and amphotericin B formulations. Most of the case series and outbreak reports have included invasive infections in adult populations.
Methods: Herein, we present a cluster of neonatal infections caused by Candida auris at a large referral center in Colombia.
Results: We report a case series of 8 neonates and infant patients who were seen at a large referral center in Colombia and who develop invasive infections caused by C. haemulonii and C. auris.
Discussion: Our report highlights the diagnostic challenges in identifying this fungal pathogen correctly, its clinical spectrum of disease, recommendations for empiric antifungal therapy, and it is not always associated with a high case fatality rate.
(© The Author(s) 2021. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze: MEDLINE
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