Immunohistochemical expression of HER - 2 and Ki - 67 in granulosa cell tumor in bitches.

Autor: Matos ACHDS; Programa de Pós-Graduação em Medicina Veterinária (Clínica e Reprodução Animal), Universidade Federal Fluminense, Niterói, Brasil., Consalter A; Programa de Pós-Graduação em Medicina Veterinária (Clínica e Reprodução Animal), Universidade Federal Fluminense, Niterói, Brasil., Dos Santos Batista BP; Programa de Pós-Graduação em Medicina Veterinária (Clínica e Reprodução Animal), Universidade Federal Fluminense, Niterói, Brasil., Fonseca ABM; Departamento de Estatística, Universidade Federal Fluminense, Niterói, Brasil., Ferreira AMR; Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niterói, Brasil., Leite JDS; Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niterói, Brasil.
Jazyk: angličtina
Zdroj: Reproduction in domestic animals = Zuchthygiene [Reprod Domest Anim] 2021 Apr; Vol. 56 (4), pp. 667-672. Date of Electronic Publication: 2021 Feb 11.
DOI: 10.1111/rda.13903
Abstrakt: Granulosa cell tumour, an ovarian neoplasm of stromal origin, is an important tumour related to oestrogenic dominance syndrome and cystic endometrial hyperplasia-pyometra complex. In order to analyse ovarian tumour´s malignant potential, immunohistochemical markers can be used, such as anti-HER2 and anti-Ki-67. The aim of this study was to evaluate the expression of immunohistochemical markers HER-2 and Ki-67 in granulosa cell tumour from bitches´ ovaries. In HER-2 immunomarker analysis using the HercepTest ® method, most tumours were classified as 2+ (moderate labelling). Concerning Ki-67 immunomarker, only one case was described as having a high proliferative index. An association was found between immunostained cell percentage by anti-HER-2 antibodies and high pleomorphism, represented by the pattern of follicular/trabecular tumour arrangement. There was no correlation between anti-Ki-67 and anti-HER-2 antibody immunostaining intensities, probably due to only one case with a high Ki-67 index. With an effective protocol for HER-2 and Ki-67 immunohistochemical identification in granulosa cell tumours in bitches, it was possible to characterize this neoplasm proliferation profile.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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