Renal arterial resistance index among subjects with liver cirrhosis in a Nigerian population.

Autor: Onwuka CC; Department of Radiology, ABUAD Multi System Hospital, Ado-Ekiti, Nigeria., Ayoola OO; Department of Radiology, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Adekanle O; Department of Medicine, Obafemi Awolowo University, Obafemi Awolowo University Teaching Hospitals, Ile-Ife, Osun State, Nigeria., Famurewa OC; Department of Radiology, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Abidoye IA; Department of Radiology, ABUAD Multi System Hospital, Ado-Ekiti, Nigeria.
Jazyk: angličtina
Zdroj: Journal of clinical ultrasound : JCU [J Clin Ultrasound] 2021 Jul; Vol. 49 (6), pp. 538-545. Date of Electronic Publication: 2021 Feb 01.
DOI: 10.1002/jcu.22985
Abstrakt: Purpose: To describe the relationship between renal artery resistance index (RARI) and liver function based on Child-Pugh system among patients with liver cirrhosis (LC) in Southwest Nigeria.
Methods: About 50 patients with LC and 50 controls were consecutively recruited into this prospective comparative case control study. Each LC patient was classed based on Child-Turcotte-Pugh (CTP) system after relevant tests. Subjects underwent abdominal ultrasonography with triplex Doppler examination of the right kidney to obtain RARI.
Results: About 50 cirrhotic and 50 controls completed the study. Age range of cirrhotic subjects was 19-69 years (mean ± SD = 47.5 ± 13.3) while that of controls was 18-69 years (46.9 ± 15.0). RARI was higher (P = <.001) in patients with LC (0.68) than in controls (0.57). RARI was also significantly higher (P = <.001) in cirrhotic subjects in CTP class C (0.72) than in those in classes B (0.66) and A (0.58). Additionally, RARI showed significant correlation with CTP total score (r = .662; P = <.001), serum bilirubin (r = .297; P = .036), serum albumin (r = -.494; P = <.001), serum sodium (r = -.369; P = .008), Model for End Stage Liver Disease (MELD) score (r = .316; P = .026) and MELD-Na score (r = .470; P = .001). RARI showed no significant relationship with serum creatinine (r = .110; P = .445) and blood urea nitrogen (r = .112; P = .437).
Conclusion: Liver cirrhosis is associated with renovascular changes which manifest as increased resistance in the renal arteries. RARI is a useful noninvasive tool for the assessment of these changes and should be done routinely in the evaluation of patients with LC.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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