Persistent infection with a rotavirus vaccine strain in a child suffering from Severe Combined Immunodeficiency in Argentina.

Autor:	Palau MJ; Sala de Microbiología, Laboratorio Central, Hospital Interzonal de Agudos Especializado en Pediatría 'Sor María Ludovica', Calle 14 n° 1631, La Plata, Argentina., Vescina CM; Sala de Microbiología, Laboratorio Central, Hospital Interzonal de Agudos Especializado en Pediatría 'Sor María Ludovica', Calle 14 n° 1631, La Plata, Argentina., Regairaz L; Servicio de Inmunología, Hospital Interzonal de Agudos Especializado en Pediatría 'Sor María Ludovica', Calle 14 n° 1631, La Plata, Argentina., Cabanillas D; Servicio de Inmunología, Hospital Interzonal de Agudos Especializado en Pediatría 'Sor María Ludovica', Calle 14 n° 1631, La Plata, Argentina., Stupka JA; Laboratorio de Gastroenteritis Virales, INEI - ANLIS 'Dr. Carlos G. Malbrán', Av Vélez Sársfield 563, Ciudad de Buenos Aires, Argentina., Degiuseppe JI; Laboratorio de Gastroenteritis Virales, INEI - ANLIS 'Dr. Carlos G. Malbrán', Av Vélez Sársfield 563, Ciudad de Buenos Aires, Argentina. Electronic address: jdegiuseppe@anlis.gov.ar.
Jazyk:	angličtina
Zdroj:	Revista Argentina de microbiologia [Rev Argent Microbiol] 2021 Jul-Sep; Vol. 53 (3), pp. 216-219. Date of Electronic Publication: 2021 Jan 30.
DOI:	10.1016/j.ram.2020.10.002
Abstrakt:	Due to the high burden of disease associated with rotavirus, the massive vaccination in children before six months of age has been encouraged. Currently licensed oral live vaccines have shown low risk of associated adverse events in the general population. Noteworthy, postmarketing reports of severe gastroenteritis with persistent vaccine viral shedding in children with severe combined immunodeficiency (SCID) have led companies to include this inborn error of immunity as an additional contraindication. SCID is not usually screened in newborns from developing countries. Therefore, the administration of live attenuated vaccines represents the first contact of these patients with life-threatening pathogens. We describe a clinical case of an infant with SCID who suffered from persistent rotavirus symptomatic diarrhea after receiving the rotavirus oral vaccine and was found to be infected with the vaccine strain. This case attempts to contribute to the discussion of those diseases that need to be incorporated into a screening program since an early diagnosis permits clinicians to withhold live attenuated immunization. (Copyright © 2020 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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