High-strength and fibrous capsule-resistant zwitterionic elastomers.

Autor:	Dong D; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA.; School of Chemical Engineering and Technology, and Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300350, China., Tsao C; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Hung HC; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Yao F; School of Chemical Engineering and Technology, and Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300350, China., Tang C; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Niu L; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Ma J; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., MacArthur J; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Sinclair A; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Wu K; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Jain P; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Hansen MR; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Ly D; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Tang SG; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Luu TM; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Jain P; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA., Jiang S; Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA. sjiang@uw.edu sj19@cornell.edu.; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2021 Jan 01; Vol. 7 (1). Date of Electronic Publication: 2021 Jan 01 (Print Publication: 2021).
DOI:	10.1126/sciadv.abc5442
Abstrakt:	The high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via a "swelling" and "locking" mechanism. These zwitterionic-elastomeric-networked (ZEN) hydrogels are further shown to efficaciously resist the fibrous capsule formation upon implantation in mice for up to 1 year. Such materials with both high mechanical properties and long-term fibrous capsule resistance have never been achieved before. This work not only demonstrates a class of durable and fibrous capsule-resistant materials but also provides design principles for zwitterionic elastomeric hydrogels. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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