High-intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial.

Autor: Brown BM; Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia. b.brown@murdoch.edu.au.; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia. b.brown@murdoch.edu.au.; Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia. b.brown@murdoch.edu.au.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. b.brown@murdoch.edu.au., Frost N; School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia., Rainey-Smith SR; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.; Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.; School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia., Doecke J; Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australia.; Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia., Markovic S; Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia., Gordon N; Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia., Weinborn M; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.; School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia., Sohrabi HR; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.; Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.; Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia., Laws SM; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia., Martins RN; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.; Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia., Erickson KI; Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA., Peiffer JJ; Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.; Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Feb 01; Vol. 13 (1), pp. 33. Date of Electronic Publication: 2021 Feb 01.
DOI: 10.1186/s13195-021-00774-y
Abstrakt: Background: Physical inactivity has been consistently linked to increased risk of cognitive decline; however, studies examining the impact of exercise interventions on cognition have produced inconsistent findings. Some observational studies suggest exercise intensity may be important for inducing cognitive improvements; however, this has yet to be thoroughly examined in older adult cohorts. The objective of the current study was to evaluate the effect of systematically manipulated high-intensity and moderate-intensity exercise interventions on cognition.
Methods: This multi-arm pilot randomised clinical trial investigated the effects of 6 months of high-intensity exercise and moderate-intensity exercise, compared with an inactive control, on cognition. Outcome measures were assessed at pre- (baseline), post- (6 months), and 12 months post-intervention. Ninety-nine cognitively normal men and women (aged 60-80 years) were enrolled from October 2016 to November 2017. Participants that were allocated to an exercise group (i.e. high-intensity or moderate-intensity) engaged in cycle-based exercise two times per week for 6 months. Cognition was assessed using a comprehensive neuropsychological test battery. Cardiorespiratory fitness was evaluated by a graded exercise test.
Results: There was a dose-dependent effect of exercise intensity on cardiorespiratory fitness, whereby the high-intensity group experienced greater increases in fitness than the moderate-intensity and control groups. However, there was no direct effect of exercise on cognition.
Conclusions: We did not observe a direct effect of exercise on cognition. Future work in this field should be appropriately designed and powered to examine factors that may contribute to individual variability in response to intervention.
Trial Registration: This study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000643370). Registered on 3 May 2017-retrospectively registered. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372780.
Databáze: MEDLINE
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