Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine.

Autor: Tejada Cifuentes F; Gerencia de Atención Integrada de Albacete, Albacete, Spain., Lloret Callejo Á; Gerencia de Atención Integrada de Albacete, Albacete, Spain., Tirado Peláez MJ; Gerencia de Atención Integrada de Albacete, Albacete, Spain., Rubio Pulido O; Gerencia de Atención Primaria de Toledo, Toledo, Spain., Ruiz-Morote Aragón M; Gerencia de Atención Integrada de Puertollano, Puertollan, Spain., Fernández Urrusuno R; Distrito Sanitario Aljarafe, Sevilla, Spain., Muñoz Carreras MI; Gerencia de Atención Integrada, Alcázar de San Juan, Alcázar de San Juan, Spain., Méndez Esteban MI; Área de Gestión Sanitaria Campo de Gibraltar, Cádiz, Spain., Maestre Sánchez V; Distrito Sanitario Condado Campiña, Huelva, Spain., García Bonilla A; Área de Gestión Sanitaria Jerez, Costa Noroeste y Sierra de Cádiz, Jerez, Spain., Paredero Dominguez JM; Gerencia de Atención Integrada, de Guadalajara, Guadalajara, Spain., Arroyo Pineda V; Gerencia de Atención Integrada Talavera de la Reina, Talavera de la Reina, Spain., Marco Tejón E; Gerencia de Atención Integrada de Cuenca, Cuenca, Spain., Romero Candel G; Gerencia de Atención Integrada de Hellín, Hellín, Spain., Fernández Marchante AI; Gerencia de Atención Integrada de Villarrobledo, Villarrobledo, Spain., Marco Del Rio J; Gerencia de Atención Integrada de Almansa, Almansa, Spain., Ortiz Martín T; Gerencia de Atención Integrada de Valdepeñas, Valdepeñas, Spain., López Sánchez P; Gerencia de Atención Integrada de Tomelloso, Tomelloso, Spain.
Jazyk: angličtina
Zdroj: Medicina clinica (English ed.) [Med Clin (Engl Ed)] 2021 Feb 26; Vol. 156 (4), pp. 166-171. Date of Electronic Publication: 2021 Jan 23.
DOI: 10.1016/j.medcle.2020.10.012
Abstrakt: Objective: To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine.
Patients and Methods: Cross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded.
Results: 169 (4,45%) patients had Covid-19 infection, of which 12 (7.1 %) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection ( P  < .05). Maculopathy appears in 5.3% of patients and is significantly related to the dose of hydroxychloroquine consumed ( P  < .05).
Conclusion: There is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19.
(© 2020 Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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