Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis.

Autor:	Jarzebska N; Department of Anesthesiology and Critical Care Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.; Division of Angiology, Department of Internal Medicine III, University Center for Vascular Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Karetnikova ES; Department of General Physiology, Saint-Petersburg State University, Saint Petersburg, Russia., Markov AG; Department of General Physiology, Saint-Petersburg State University, Saint Petersburg, Russia., Kasper M; Institute of Anatomy, Technische Universität Dresden, Dresden, Germany., Rodionov RN; Division of Angiology, Department of Internal Medicine III, University Center for Vascular Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Spieth PM; Department of Anesthesiology and Critical Care Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2021 Jan 15; Vol. 7, pp. 585756. Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2020).
DOI:	10.3389/fmed.2020.585756
Abstrakt:	Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Jarzebska, Karetnikova, Markov, Kasper, Rodionov and Spieth.)
Databáze:	MEDLINE
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