Macrophage Plasticity in Reproduction and Environmental Influences on Their Function.
| Autor: | Chambers M; Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom., Rees A; Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom., Cronin JG; Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom., Nair M; Maternity and Child Health, Singleton Hospital, Swansea Bay University Health Board, Swansea, United Kingdom., Jones N; Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom., Thornton CA; Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 Jan 14; Vol. 11, pp. 607328. Date of Electronic Publication: 2021 Jan 14 (Print Publication: 2020). |
| DOI: | 10.3389/fimmu.2020.607328 |
| Abstrakt: | Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning reproductive success including implantation, placentation and parturition. Macrophages are also present in breast milk and impart immunomodulatory benefits to the infant. For a healthy pregnancy, the maternal immune system must adapt to prevent fetal rejection and support development of the semi-allogenic fetus without compromising host defense. These functions are dependent on macrophage polarization which is governed by the local tissue microenvironmental milieu. Disruption of this microenvironment, possibly by environmental factors of infectious and non-infectious origin, can affect macrophage phenotype and function and is linked to adverse obstetric outcomes, e.g. spontaneous miscarriage and preterm birth. Determining environmental influences on cellular and molecular mechanisms that control macrophage polarization at the maternal-fetal interface and the role of this in pregnancy complications could support approaches to alleviating adverse pregnancy outcomes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Chambers, Rees, Cronin, Nair, Jones and Thornton.) |
| Databáze: | MEDLINE |
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