Simulating Dynamics of Circulation in the Awake State and Different Stages of Sleep Using Non-autonomous Mathematical Model With Time Delay.

Autor:	Karavaev AS; Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Saratov, Russia.; Smart Sleep Laboratory, Saratov State University, Saratov, Russia.; Department of Innovative Cardiological Information Technology, Saratov State Medical University, Saratov, Russia., Ishbulatov YM; Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Saratov, Russia.; Smart Sleep Laboratory, Saratov State University, Saratov, Russia.; Department of Innovative Cardiological Information Technology, Saratov State Medical University, Saratov, Russia., Prokhorov MD; Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Saratov, Russia.; Smart Sleep Laboratory, Saratov State University, Saratov, Russia., Ponomarenko VI; Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Saratov, Russia., Kiselev AR; Department of Innovative Cardiological Information Technology, Saratov State Medical University, Saratov, Russia., Runnova AE; Smart Sleep Laboratory, Saratov State University, Saratov, Russia.; Department of Innovative Cardiological Information Technology, Saratov State Medical University, Saratov, Russia., Hramkov AN; Smart Sleep Laboratory, Saratov State University, Saratov, Russia., Semyachkina-Glushkovskaya OV; Smart Sleep Laboratory, Saratov State University, Saratov, Russia., Kurths J; Smart Sleep Laboratory, Saratov State University, Saratov, Russia.; Physics Department, Humboldt University of Berlin, Berlin, Germany.; Research Department Complexity Science, Potsdam Institute for Climate Impact Research (PIK), Potsdam, Germany., Penzel T; Smart Sleep Laboratory, Saratov State University, Saratov, Russia.; Interdisciplinary Sleep Medicine Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2021 Jan 13; Vol. 11, pp. 612787. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2020).
DOI:	10.3389/fphys.2020.612787
Abstrakt:	We propose a mathematical model of the human cardiovascular system. The model allows one to simulate the main heart rate, its variability under the influence of the autonomic nervous system, breathing process, and oscillations of blood pressure. For the first time, the model takes into account the activity of the cerebral cortex structures that modulate the autonomic control loops of blood circulation in the awake state and in various stages of sleep. The adequacy of the model is demonstrated by comparing its time series with experimental records of healthy subjects in the SIESTA database. The proposed model can become a useful tool for studying the characteristics of the cardiovascular system dynamics during sleep. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Karavaev, Ishbulatov, Prokhorov, Ponomarenko, Kiselev, Runnova, Hramkov, Semyachkina-Glushkovskaya, Kurths and Penzel.)
Databáze:	MEDLINE
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