An open clinical evaluation of selected siddha regimen in expediting the management of COVID-19 -a randomized controlled study.

Autor:	Chitra SM; Department of Maruthuvam, Government Siddha Medical College, Chennai, 600106, Tamil Nadu, India. Electronic address: chittu758@gmail.com., Mallika P; Aringnar Anna Government Hospital of Indian Medicine, Chennai, 600106, Tamil Nadu, India., Anbu N; Department of Maruthuvam, Government Siddha Medical College, Chennai, 600106, Tamil Nadu, India., Narayanababu R; Directorate of Medical Education, Kilpauk, Chennai, 600010, Tamil Nadu, India., Sugunabai A; Government Medical College, Omandurar Estate Campus, Chennai, 600002, Tamil Nadu, India., David Paul Raj RS; Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, India., Premnath D; Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, India.
Jazyk:	angličtina
Zdroj:	Journal of Ayurveda and integrative medicine [J Ayurveda Integr Med] 2022 Jan-Mar; Vol. 13 (1), pp. 100397. Date of Electronic Publication: 2021 Jan 21.
DOI:	10.1016/j.jaim.2021.01.002
Abstrakt:	Background: The corona virus disease 2019 (COVID-19), an acute respiratory disease, caused by a novel corona virus (SARS-CoV-2, previously known as 2019-nCoV), obtained worldwide attention. In this review, we explored the potential siddha strategies for COVID -19 infections. Objectives: To evaluate the additional benefits of siddha drugs Vasantha kusumakaram mathirai, Thippili rasayanam, Adathodai manapagu and Kabasura kudineer compared to the allopathic standard treatment of care alone in COVID-19 asymptomatic, mild - moderate cases. Materials and Methods: The present study was an open label Two arm - randomized controlled interventional clinical study. The Group I patients were assigned to Siddha add on treatment whereas Group II subjects were assigned with standard treatment alone. The sample size was 100 for each group. Result: The average number of days taken for reduction of symptoms showed significant results (P < 0.001) in Siddha add on compared with standard treatment. The real - time polymerase chain reaction (RT-PCR) investigation turned negative for 78.33% in Siddha add on and 33.33% in standard treatment after 11-14 days. Similarly, CT chest, covid pattern lung involvement percentage showed highly significant reduction (P < 0.0001) in Siddha add on treatment. In addition, Neutrophil Lymphocyte Ratio (NLR) ratio, showed significant reduction (P < 0.01) when analyzed by Wilcoxon signed rank test, and Renal, Liver parameters were within the normal limits in Siddha add on Group for 25 samples in post treatment. Conclusion: Finally, it was concluded that Siddha add on Group showed accelerated recovery for COVID - 19 patients compared to standard Group. The synergistic effect of Siddha add on with standard treatment gave more promising results in the current study of COVID -19. Competing Interests: None (© 2021 The Authors.)
Databáze:	MEDLINE
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