Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study).

Autor:	Cheong J; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia jeanie.cheong@thewomens.org.au.; Newborn Research, Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria, Australia., Cameron KLI; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia., Thompson D; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia., Anderson PJ; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia., Ranganathan S; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.; Respiratory Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.; Respiratory Diseases, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Clark R; Research Health Institute, University of the Sunshine Coast, Sunshine Coast, Queensland, Australia., Mentiplay B; La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia., Burnett A; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Newborn Research, Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Neonatal Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia., Lee K; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.; Clinical Epidemiology and Biostatistics, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Doyle LW; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Newborn Research, Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia., Spittle AJ; Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Newborn Research, Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2021 Jan 31; Vol. 11 (1), pp. e044491. Date of Electronic Publication: 2021 Jan 31.
DOI:	10.1136/bmjopen-2020-044491
Abstrakt:	Introduction: Children born moderate to late preterm (MLP, 32-36 weeks' gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years. Methods and Analysis: The "LaPrem" ( La te Pre term M RI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women's Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression. Ethics and Dissemination: This study was approved by the human research ethics committee at the Royal Children's Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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