Genome-wide association studies for mottled eggs in chickens using a high-density single-nucleotide polymorphism array.

Autor: Qu L; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Shen MM; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China; College of Biotechnology, Jiangsu University of Science and Technology, 212003 Zhenjiang, Jiangsu, China., Dou TC; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Ma M; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Lu J; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Wang XG; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Guo J; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Hu YP; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Li YF; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China., Wang KH; Jiangsu Institute of Poultry Science, Chinese Academy of Agricultural Sciences, 225125 Yangzhou, Jiangsu, China. Electronic address: sqbreeding@126.com.
Jazyk: angličtina
Zdroj: Animal : an international journal of animal bioscience [Animal] 2021 Jan; Vol. 15 (1), pp. 100051. Date of Electronic Publication: 2020 Dec 10.
DOI: 10.1016/j.animal.2020.100051
Abstrakt: Mottled eggs in layer chickens are gaining increasing attention because of the economic impact on the egg industry caused by the reduced sale value of commodity eggs. However, the genetic architecture underlying mottled eggs is not well understood. The genetic architecture underlying the mottled egg trait was investigated using genome-wide association studies (GWAS) by high-density arrays, using a total of 407 pink eggs and 799 blue eggs from an F 2 resource population generated by crossing Dongxiang Blue-shelled and White Leghorn chickens. The mottled egg score in blue eggs was found to be higher than that in pink eggs. The single-nucleotide polymorphism heritability of mottled egg at laying day and storage for 7 days was 0.18 and 0.20, respectively. Bivariate GWAS provided 29 significant loci, mainly located on GGA2, GGA3, GGA8, GGA10, GGA15, GGA17, and GGA23, affecting mottled egg on laying day. Candidate genes RIMS2, SLC25A32, RIMBP2, VPS13B, and RGS3 were obtained for mottled eggshell by bivariate GWAS and gene annotation. Our findings provide new insights into the genetic architecture of mottled egg in hens, and demonstrate that a genomic selection method would be profitable for breeding out the mottled egg trait.
(Copyright © 2020. Published by Elsevier B.V.)
Databáze: MEDLINE
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