Comparison of human peripheral blood dendritic cell activation by four fucoidans.

Autor: Zhang W; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China., Park HB; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, South Korea., Yadav D; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea., Hwang J; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, South Korea., An EK; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, South Korea., Eom HY; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea., Kim SJ; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea., Kwak M; Department of Chemistry, Pukyong National University, Busan 48513, South Korea., Lee PC; Department of Biomedical Sciences, University of Ulsan College of Medicine, ASAN Medical Center, Seoul 05505, South Korea. Electronic address: pclee@amc.seoul.kr., Jin JO; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China; Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, South Korea. Electronic address: jinjo@yu.ac.kr.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2021 Mar 31; Vol. 174, pp. 477-484. Date of Electronic Publication: 2021 Jan 26.
DOI: 10.1016/j.ijbiomac.2021.01.155
Abstrakt: Brown seaweed is an important source of fucoidan, which displays immunomodulatory effects by activating various immune cells. However, these effects of fucoidans from various sources of brown seaweed have not yet been explored in human blood dendritic cells. We studied fucoidans extracted from Ecklonia cava, Macrocystis pyrifera, Undaria pinnatifida, and Fucus vesiculosus for their effects on human monocyte-derived dendritic cells (MODC) and human peripheral blood DC (PBDC) activation. Ecklonia cava fucoidan (ECF) strongly upregulated co-stimulatory molecules, major histocompatibility complex class I and II, and the production of proinflammatory cytokines in MODCs and PBDCs compared to those by the other three fucoidans. Moreover, ECF elicited the strongest effect in the induction of syngeneic T cell proliferation and IFN-γ production compared to those of other fucoidans. These results suggest that ECF could be a suitable candidate molecule for enhancing immune activation in humans compared to that with the other three fucoidans.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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