Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia.

Autor:	Litts KM; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA., Woertz EN; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA., Georgiou M; UCL Institute of Ophthalmology, University College London, London, UK.; Moorfields Eye Hospital NHS Foundation Trust, London, UK., Patterson EJ; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA., Lam BL; Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA., Fishman GA; Pangere Center for Inherited Retinal Diseases, The Chicago Lighthouse, Chicago, IL, USA., Pennesi ME; Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA., Kay CN; Vitreoretinal Associates, Gainesville, FL, USA., Hauswirth WW; Department of Ophthalmology, University of Florida, Gainesville, FL, USA., Michaelides M; UCL Institute of Ophthalmology, University College London, London, UK.; Moorfields Eye Hospital NHS Foundation Trust, London, UK., Carroll J; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2021 Jan 07; Vol. 10 (1), pp. 11. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2021).
DOI:	10.1167/tvst.10.1.11
Abstrakt:	Purpose: To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods: Previously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3 ) were reviewed along with best-corrected visual acuity (BCVA) and axial length. OCT artifacts in interpolated vertical volumes from CIRRUS macular cubes were divided into four categories: (1) none or minimal, (2) clear and low frequency, (3) low amplitude and high frequency, and (4) high amplitude and high frequency. Each vertical volume was assessed once by two observers. AOSLO success was defined as sufficient image quality in split-detector images at the fovea to assess cone quantity. Results: There was excellent agreement between the two observers for assessing OCT artifact severity category (weighted kappa = 0.88). Overall, AOSLO success was 47%. For subjects with OCT artifact severity category 1, AOSLO success was 65%; for category 2, 47%; for category 3, 11%; and for category 4, 0%. There was a significant association between OCT artifact severity category and AOSLO success ( P = 0.0002). Neither BCVA nor axial length was associated with AOSLO success ( P = 0.07 and P = 0.75, respectively). Conclusions: Artifacts in OCT volumes are associated with AOSLO success in ACHM. Subjects with less severe OCT artifacts are more likely to be good candidates for AOSLO imaging, whereas AOSLO was successful in only 7% of subjects with category 3 or 4 OCT artifacts. These results may be useful in guiding patient selection for AOSLO imaging. Translational Relevance: Using OCT to prescreen patients could be a valuable tool for clinical trials that utilize AOSLO to reduce costs and decrease patient testing burden. Competing Interests: Disclosure: K.M. Litts, None; E.N. Woertz, None; M. Georgiou, MeiraGTx (C); E.J. Patterson, None; B.L. Lam, AGTC (F), G.A. Fishman, AGTC (F); M.E. Pennesi, AGTC (F); C.N. Kay, AGTC (F); W.W. Hauswirth, AGTC (I, R); M. Michaelides, MeiraGTx (C); J. Carroll, MeiraGTx (C, F), OptoVue (F), AGTC (F), Translational Imaging Innovations (I) (Copyright 2021 The Authors.)
Databáze:	MEDLINE
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