Pharmacovigilance of Antiretroviral Drugs at B.P. Koirala Institute of Health sciences.

Autor:	Sarraf DP; Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Rauniar GP; Department of Clinical Pharmacology and Therapeutics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Chhetri R; Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Kafle SP; Department of Pediatrics and Adolescents medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Marahatta S; Department of Dermatology and Venereology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Khanal B; Department of Microbiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Sharma SK; Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal., Kattel V; Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Jazyk:	angličtina
Zdroj:	Journal of Nepal Health Research Council [J Nepal Health Res Counc] 2021 Jan 21; Vol. 18 (4), pp. 596-603. Date of Electronic Publication: 2021 Jan 21.
DOI:	10.33314/jnhrc.v18i4.2634
Abstrakt:	Background: Antiretroviral drugs are lifeline for patients living with HIV. Adverse drug reactions can compromise the compliance to antiretroviral therapy. The objectives of the study were to estimate the prevalence of adverse drug reactions and to assess its risk factors in patients living with HIV and receiving antiretroviral therapy. Methods: A prospective cohort study was conducted among 496 patients living with HIV at B.P. Koirala Institute of Health Sciences for a period of one year. Adverse drug reactions were evaluated based upon clinical history, clinical examination and investigations. Results: Majority of patients were of 31-45 year age group (58.1%) and on first-line antiretroviral therapy regimen (94.3%). Total of 240 adverse drug reactions were documented. Prevalence of adverse drug reaction was 34.7%. Skin rash, anemia and nausea and vomiting were the three most common adverse drug reactions. The adverse drug reactions were more common in patients having non-communicable diseases, chronic co-infections, taking more than 3 non-HIV drugs, second and third-line antiretroviral regimen and it was statistically significant (P-value < 0.05). Conclusions: Prevalence of adverse drug reaction was high in the patients living with HIV. Age, gender, co-infections, non-communicable diseases, taking more than three non-HIV drugs and second and third-line antiretroviral regimen were identified as possible risk factor for occurrence of adverse drug reactions and their prior identification is important to optimize the best suited antiretroviral regimen.
Databáze:	MEDLINE
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