Microstructural Tissue Changes in Alzheimer Disease Brains: Insights from Magnetization Transfer Imaging.

Autor:	Colonna I; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.)., Koini M; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.)., Pirpamer L; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.)., Damulina A; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.)., Hofer E; Institute for Medical Informatics, Statistics and Documentation (E.H.)., Schwingenschuh P; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.)., Enzinger C; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.).; Division of Neuroradiology, Vascular & Interventional Radiology, Department of Radiology (C.E.), Medical University of Graz, Graz, Austria., Schmidt R; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.) reinhold.schmidt@medunigraz.at., Ropele S; From the Department of Neurology (I.C., M.K., L.P., A.D., P.S., C.E., R.S., S.R.).
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2021 Apr; Vol. 42 (4), pp. 688-693. Date of Electronic Publication: 2021 Jan 28.
DOI:	10.3174/ajnr.A6975
Abstrakt:	Background and Purpose: Reductions in magnetization transfer ratio have been associated with brain microstructural damage. We aim to compare magnetization transfer ratio in global and regional GM and WM between individuals with Alzheimer disease and healthy control participants to analyze the relationship between magnetization transfer ratio and cognitive functioning in Alzheimer disease. Materials and Methods: In this prospective study, participants with Alzheimer disease and a group of age-matched healthy control participants underwent clinical examinations and 3T MR imaging. Magnetization transfer ratios were determined in the cortex, AD-signature regions, normal-appearing WM, and WM hyperintensities. Results: Seventy-seven study participants (mean age ± SD, 72 ± 8 years; 47 female) and 77 age-matched healthy control participants (mean age ± SD, 72 ± 8 years; 44 female) were evaluated. Magnetization transfer ratio values were lower in patients with Alzheimer disease than in healthy control participants in all investigated regions. When adjusting for atrophy and extent of WM hyperintensities, significant differences were seen in the global cortex (OR = 0.47; 95% CI: 0.22, 0.97; P = .04), in Alzheimer disease-signature regions (OR = 0.31; 95% CI: 0.14, 0.67; P = .003), in normal-appearing WM (OR = 0.59; 95% CI: 0.39, 0.88; P = .01), and in WM hyperintensities (OR = 0.18; 95% CI: 0.09, 0.33; P  ≤ .001). The magnetization transfer ratio in these regions was an independent determinant of AD. When correcting for atrophy and WM hyperintensity extent, lower GM magnetization transfer ratios were associated with poorer global cognition, language function, and constructional praxis. Conclusions: Alzheimer disease is associated with magnetization transfer ratio reductions in GM and WM regions of the brain. Lower magnetization transfer ratios in the entire cortex and AD-signature regions contribute to cognitive impairment independent of brain atrophy and WM damage. (© 2021 by American Journal of Neuroradiology.)
Databáze:	MEDLINE
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