Clinical Characteristics and Diagnostic Challenges of COVID-19: An Update From the Global Perspective.

Autor:	Israfil SMH; Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh., Sarker MMR; Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.; Pharmacology and Toxicology Research Division, Health Med Science Research Limited, Dhaka, Bangladesh., Rashid PT; Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh., Talukder AA; Department of Microbiology, Jahangirnagar University, Savar, Bangladesh., Kawsar KA; Department of Neurosurgery, St. Georges Hospital, London, United Kingdom., Khan F; Pharmacology and Toxicology Research Division, Health Med Science Research Limited, Dhaka, Bangladesh., Akhter S; Department of Public Health, Daffodil International University, Dhaka, Bangladesh., Poh CL; Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, Petaling Jaya, Malaysia., Mohamed IN; Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia (The National University of Malaysia), Cheras, Malaysia., Ming LC; PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2021 Jan 11; Vol. 8, pp. 567395. Date of Electronic Publication: 2021 Jan 11 (Print Publication: 2020).
DOI:	10.3389/fpubh.2020.567395
Abstrakt:	Clinical characteristics are essential for the correct diagnosis of diseases. The current review aimed to summarize the global clinical characteristics of the COVID-19 patients systematically and identify their diagnostic challenges to help the medical practitioners properly diagnose and for better management of COVID-19 patients. We conducted a systematic search in PubMed, Web of Science, Scopus, Science Direct, and Google Scholar databases for original articles containing clinical information of COVID-19 published up to 7th May 2020. Two researchers independently searched the databases to extract eligible articles. A total of 34 studies from 8 different countries with 10889 case-patients were included for clinical characteristics. The most common clinical symptoms were cough 59.6, fever 46.9, fatigue 27.8, and dyspnea 20.23%. The prominent laboratory findings were lymphocytopenia 55.9, elevated levels of CRP 61.9, aspartate aminotransferase 53.3, LDH 40.8, ESR 72.99, serum ferritin 63, IL-6 52, and prothrombin time 35.47%, and decreased levels of platelets 17.26, eosinophils 59.0, hemoglobin 29, and albumin 38.4%. CT scan of the chest showed an abnormality in 93.50% cases with bilateral lungs 71.1%, ground-glass opacity 48%, lesion in lungs 78.3%, and enlargement of lymph node 50.7%. Common comorbidities were hypertension, diabetes, obesity, and cardiovascular diseases. The estimated median incubation period was 5.36 days, and the overall case fatality rate was 16.9% (Global case fatality outside China was 22.24%: USA 21.24%, Italy 25.61%, and others 0%; whereas the case fatality inside the Hubei Province of China was found to be 11.71%). Global features on the clinical characteristics of COVID-19 obtained from laboratory tests and CT scan results will provide useful information to the physicians to diagnose the disease and for better management of the patients as well as to address the diagnostic challenges to control the infection. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Israfil, Sarker, Rashid, Talukder, Kawsar, Khan, Akhter, Poh, Mohamed and Ming.)
Databáze:	MEDLINE
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