COVID-19 and Spinal Cord Injury: Clinical Presentation, Clinical Course, and Clinical Outcomes: A Rapid Systematic Review.

Autor: Hoogenes B; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.; Faculty of Medicine, University of Amsterdam, Amsterdam, Netherlands.; Rehabilitation Research Program, University of British Columbia, Vancouver, British Columbia, Canada., Querée M; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.; Rehabilitation Research Program, University of British Columbia, Vancouver, British Columbia, Canada., Townson A; Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada.; G.F. Strong Rehabilitation Centre, Vancouver, British Columbia, Canada., Willms R; Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada.; G.F. Strong Rehabilitation Centre, Vancouver, British Columbia, Canada., Eng JJ; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.; Rehabilitation Research Program, University of British Columbia, Vancouver, British Columbia, Canada.
Jazyk: angličtina
Zdroj: Journal of neurotrauma [J Neurotrauma] 2021 May 01; Vol. 38 (9), pp. 1242-1250. Date of Electronic Publication: 2021 Jan 27.
DOI: 10.1089/neu.2020.7461
Abstrakt: Persons living with spinal cord injury (SCI) are potentially at risk for severe COVID-19 disease given that they often have decreased lung capacity and may lack the ability to effectively evacuate their lungs. Known risk factors for negative outcomes after COVID-19, such as obesity, diabetes, and cardiovascular disease, disproportionally affect people with SCI and raise concerns for the mortality risk among persons with SCI. A rapid systematic review of English, Spanish, Portuguese, and Chinese literature on COVID-19 and SCI was performed using the keywords "spinal cord injury" and "COVID-19." We included studies that provided information on clinical presentation, characteristics, course, and outcomes of COVID-19 disease in SCI. We excluded studies on patients who did not have an SCI before severe acute respiratory syndrome coronavirus-2 infection or did not report clinical information. We included 10 studies in total: nine studies with a total of 171 patients and a survey study of 783 healthcare professionals. Fever (74%), cough (52%), and dyspnea (33%) were the most frequently reported symptoms, and 63% showed abnormalities on X-ray imaging. In the included case series and reports ( N  = 31), only 1 patient required mechanical ventilation, but 3 patients died (10%). The mortality rate in a large registry study ( N  = 140) was 19%. Clinical presentation of COVID-19 in SCI patients was similar to the general population, and though adverse events and intensive care unit admission were low, the mortality rate was high (10-19%). No prognostic factors for severe disease or mortality could be identified. Registration (PROSPERO): CRD42020196565.
Databáze: MEDLINE
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