Effect of Vaccination on Preventing Influenza-Associated Hospitalizations Among Children During a Severe Season Associated With B/Victoria Viruses, 2019-2020.

Autor:	Campbell AP; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Ogokeh C; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA., Weinberg GA; University of Rochester School of Medicine and Dentistry, Rochester, New York, USA., Boom JA; Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA., Englund JA; Seattle Children's Hospital, Seattle, Washington, USA., Williams JV; Department of Pediatrics, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA., Halasa NB; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Selvarangan R; Children's Mercy Hospital, Kansas City, Missouri, USA.; Department of Pathology and Laboratory Medicine, University of Missouri-Kansas City, Children's Mercy Hospital, Kansas City, Missouri, USA., Staat MA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Klein EJ; Seattle Children's Hospital, Seattle, Washington, USA., McNeal M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Michaels MG; Department of Pediatrics, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA., Sahni LC; Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA., Stewart LS; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Szilagyi PG; University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.; University of California at Los Angeles, Los Angeles, California, USA., Harrison CJ; Children's Mercy Hospital, Kansas City, Missouri, USA., Lively JY; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; IHRC, Atlanta, Georgia, USA., Rha B; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Patel M; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Aug 16; Vol. 73 (4), pp. e947-e954.
DOI:	10.1093/cid/ciab060
Abstrakt:	Background: The 2019-2020 influenza season was characterized by early onset with B/Victoria followed by A(H1N1)pdm09 viruses. Emergence of new B/Victoria viruses raised concerns about possible vaccine mismatch. We estimated vaccine effectiveness (VE) against influenza-associated hospitalizations and emergency department (ED) visits among children in the United States. Methods: We assessed VE among children aged 6 months-17 years with acute respiratory illness and ≤10 days of symptoms enrolled at 7 pediatric medical centers in the New Vaccine Surveillance Network. Combined midturbinate/throat swabs were tested for influenza virus using molecular assays. Vaccination history was collected from parental report, state immunization information systems, and/or provider records. We estimated VE from a test-negative design using logistic regression to compare odds of vaccination among children testing positive vs negative for influenza. Results: Among 2029 inpatients, 335 (17%) were influenza positive: 37% with influenza B/Victoria alone and 44% with influenza A(H1N1)pdm09 alone. VE was 62% (95% confidence interval [CI], 52%-71%) for influenza-related hospitalizations, 54% (95% CI, 33%-69%) for B/Victoria viruses, and 64% (95% CI, 49%-75%) for A(H1N1)pdm09. Among 2102 ED patients, 671 (32%) were influenza positive: 47% with influenza B/Victoria alone and 42% with influenza A(H1N1)pdm09 alone. VE was 56% (95% CI, 46%-65%) for an influenza-related ED visit, 55% (95% CI, 40%-66%) for B/Victoria viruses, and 53% (95% CI, 37%-65%) for A(H1N1)pdm09. Conclusions: Influenza vaccination provided significant protection against laboratory-confirmed influenza-associated hospitalizations and ED visits associated with the 2 predominantly circulating influenza viruses among children, including against the emerging B/Victoria virus subclade. (Published by Oxford University Press for the Infectious Diseases Society of America 2021.)
Databáze:	MEDLINE
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