High-protein vs. standard-protein diets in overweight and obese patients with heart failure and diabetes mellitus: findings of the Pro-HEART trial.

Autor: Evangelista LS; School of Nursing, University of Texas Medical Branch, Galveston, TX, 77555-1132, USA., Jose MM; School of Nursing, University of Texas Medical Branch, Galveston, TX, 77555-1132, USA., Sallam H; Diabetes Prevention and Care Program, University of Texas Medical Branch, Galveston, TX, USA., Serag H; Diabetes Prevention and Care Program, University of Texas Medical Branch, Galveston, TX, USA., Golovko G; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Khanipov K; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Hamilton MA; Department of Medicine/Cardiology, University of California, Los Angeles, Los Angeles, CA, USA.; Heart Failure Program, Cedars-Sinai Heart Institute, Los Angeles, CA, USA., Fonarow GC; Ahmanson-UCLA Cardiomyopathy Center and Cardiology, University of California, Los Angeles, Los Angeles, CA, USA.
Jazyk: angličtina
Zdroj: ESC heart failure [ESC Heart Fail] 2021 Apr; Vol. 8 (2), pp. 1342-1348. Date of Electronic Publication: 2021 Jan 27.
DOI: 10.1002/ehf2.13213
Abstrakt: Aims: The intermediate-term effects of dietary protein on cardiometabolic risk factors in overweight and obese patients with heart failure and diabetes mellitus are unknown. We compared the effect of two calorie-restricted diets on cardiometabolic risk factors in this population.
Methods and Results: In this randomized controlled study, 76 overweight and obese (mean weight, 107.8 ± 20.8 kg) patients aged 57.7 ± 9.7 years, 72.4% male, were randomized to a high-protein (30% protein, 40% carbohydrates, and 30% fat) or standard-protein diet (15% protein, 55% carbohydrates, and 30% fat) for 3 months. Reductions in weight and cardiometabolic risks were evaluated at 3 months. Both diets were equally effective in reducing weight (3.6 vs. 2.9 kg) and waist circumference (1.9 vs. 1.3 cm), but the high-protein diet decreased to a greater extent glycosylated haemoglobin levels (0.7% vs. 0.1%, P = 0.002), cholesterol (16.8 vs. 0.9 mg/dL, P = 0.031), and triglyceride (25.7 vs. 5.7 mg/dL, P = 0.032), when compared with the standard-protein diet. The high-protein diet also significantly improved both systolic and diastolic blood pressure than the standard-protein diet (P < 0.001 and P = 0.040, respectively).
Conclusions: Both energy-restricted diets reduced weight and visceral fat. However, the high-protein diet resulted in greater reductions in cardiometabolic risks relative to a standard-protein diet. These results suggest that a high-protein diet may be more effective in reducing cardiometabolic risk in this population, but further trials of longer duration are needed.
(© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Databáze: MEDLINE
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