Genomic Evidence for Sequestration of Influenza A Virus Lineages in Sea Duck Host Species.

Autor: McBride DS; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA., Lauterbach SE; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA., Li YT; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore., Smith GJD; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore., Killian ML; Diagnostic Virology Laboratory, National Veterinary Services Laboratories, APHIS, USDA, 1920 Dayton Avenue, Ames, IA 50010, USA., Nolting JM; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA., Su YCF; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore., Bowman AS; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2021 Jan 24; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 24.
DOI: 10.3390/v13020172
Abstrakt: Wild birds are considered the natural reservoir of influenza A viruses (IAVs) making them critical for IAV surveillance efforts. While sea ducks have played a role in novel IAV emergence events that threatened food security and public health, very few surveillance samples have been collected from sea duck hosts. From 2014-2018, we conducted surveillance focused in the Mississippi flyway, USA at locations where sea duck harvest has been relatively successful compared to our other sampling locations. Our surveillance yielded 1662 samples from sea ducks, from which we recovered 77 IAV isolates. Our analyses identified persistence of sea duck specific IAV lineages across multiple years. We also recovered sea duck origin IAVs containing an H4 gene highly divergent from the majority of North American H4-HA with clade node age of over 65 years. Identification of IAVs with long branch lengths is indicative of substantial genomic change consistent with persistence without detection by surveillance efforts. Sea ducks play a role in the movement and long-term persistence of IAVs and are likely harboring more undetected IAV diversity. Sea ducks should be a point of emphasis for future North American wild bird IAV surveillance efforts.
Databáze: MEDLINE
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