| Autor: |
Druzina AA; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia., Zhidkova OB; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia., Dudarova NV; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia., Kosenko ID; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia., Ananyev IV; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia., Timofeev SV; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia., Bregadze VI; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia. |
| Abstrakt: |
Novel zwitter-ionic nido -carboranyl azide 9-N 3 (CH 2 ) 3 Me 2 N- nido -7,8-C 2 B 9 H 11 was prepared by the reaction of 9-Cl(CH 2 ) 3 Me 2 N- nido -7,8-C 2 B 9 H 11 with NaN 3 . The solid-state molecular structure of nido -carboranyl azide was determined by single-crystal X-ray diffraction. 9-N 3 (CH 2 ) 3 Me 2 N- nido -7,8-C 2 B 9 H 11 was used for the copper(I)-catalyzed azide-alkyne cycloaddition with phenylacetylene, alkynyl-3β-cholesterol and cobalt/iron bis(dicarbollide) terminal alkynes to form the target 1,2,3-triazoles. The nido -carborane-cholesterol conjugate 9-3β-Chol-O(CH 2 )C-CH-N 3 (CH 2 ) 3 Me 2 N- nido -7,8-C 2 B 9 H 11 with charge-compensated group in a linker can be used as a precursor for preparation of liposomes for Boron Neutron Capture Therapy (BNCT). A series of novel zwitter-ionic boron-enriched cluster compounds bearing a 1,2,3-triazol-metallacarborane-carborane conjugated system was synthesized. Prepared conjugates contain a large amount of boron atom in the biomolecule and potentially can be used for BNCT. |
