Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia.

Autor:	Advani AS; Cleveland Clinic Taussig Cancer Institute, Cleveland, OH., Larsen E; Maine Children's Cancer Program, Scarborough, ME., Laumann K; Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN., Luger SM; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA., Liedtke M; Stanford Medical Center, Stanford, CA., Devidas M; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TX., Chen Z; Department of Biostatistics, University of Florida, Gainesville, FL., Yin J; Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN., Foster MC; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC., Claxton D; Penn State Cancer Institute, Hershey, PA., Coffan K; Children's Hospital of Philadelphia, Pennsylvania, PA., Tallman MS; Memorial Sloan-Kettering Cancer Center, New York, NY., Appelbaum FR; Fred Hutchinson Cancer Center; Seattle, WA., Erba H; Duke Cancer Institute, Duke University Medical Center, Durham, NC., Stone RM; Dana-Farber/Partners CancerCare, Boston, MA., Hunger SP; Center for Childhood Cancer Research and the Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., McNeer JL; University of Chicago Comer Children's Hospital, Chicago, IL., Loh ML; Department of Pediatrics, Benioff Children's Hospital, and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Raetz E; NYU Langone Health, New York, NY., Winick N; University of Texas Southwestern Medical Center, Dallas, TX; and., Carroll W; NYU Langone Health, New York, NY., Larson RA; University of Chicago Comprehensive Cancer Center, Chicago, IL., Stock W; University of Chicago Comprehensive Cancer Center, Chicago, IL.
Jazyk:	angličtina
Zdroj:	Blood advances [Blood Adv] 2021 Jan 26; Vol. 5 (2), pp. 504-512.
DOI:	10.1182/bloodadvances.2020002439
Abstrakt:	Adolescents and young adults (AYAs) with acute lymphoblastic leukemia have improved outcomes when treated with pediatric-inspired regimens. CALGB 10403 was the largest prospective study to evaluate the feasibility of using a pediatric regimen in AYAs with acute lymphoblastic leukemia up to 40 years of age. This article presents the toxicity events observed in the CALGB 10403 study and compares these toxicities vs those observed among AYAs treated on the same arm of the companion Children's Oncology Group (COG) AALL0232 study. Toxicities in CALGB 10403 were similar to those observed in COG AALL0232. Some grade 3 to 4 adverse events were more often reported in CALGB 10403 compared with COG AALL0232 (hyperglycemia, hyperbilirubinemia, transaminase elevation, and febrile neutropenia). Adverse events correlated with body mass index ≥30 kg/m2 and some with increasing age. The mortality rate in CALGB 10403 was low (4%) and similar to that in the COG AALL0232 trial. A caveat to this analysis is that only 39% of CALGB 10403 patients completed all planned protocol treatment. In COG AALL0232, although 74% of patients aged <18 years completed treatment, only 57% of patients aged ≥18 years completed treatment. This scenario suggests that issues associated with age and treating physician may be a factor. Due to its improved survival rates compared with historical controls, the CALGB 10403 regimen is now a standard of care. The hope is that the rate of protocol completion will increase as more familiarity is gained with this regimen. These trials were registered at www.clinicaltrials.gov as #NCT00558519 (CALGB 10403) and #NCT00075725 (COG AALL0232). (© 2021 by The American Society of Hematology.)
Databáze:	MEDLINE
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