Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction.

Autor:	Casarotti ACA; Universidade Federal de São Paulo, São Paulo, Brazil., Teixeira D; Universidade Federal de São Paulo, São Paulo, Brazil., Longo-Maugeri IM; Universidade Federal de São Paulo, São Paulo, Brazil., Ishimura ME; Universidade Federal de São Paulo, São Paulo, Brazil., Coste MER; Universidade Federal de São Paulo, São Paulo, Brazil., Bianco HT; Universidade Federal de São Paulo, São Paulo, Brazil., Moreira FT; Universidade Federal de São Paulo, São Paulo, Brazil., Bacchin AF; Universidade Federal de São Paulo, São Paulo, Brazil., Izar MC; Universidade Federal de São Paulo, São Paulo, Brazil., Gonçalves I; Universidade Federal de São Paulo, São Paulo, Brazil., Caixeta A; Universidade Federal de São Paulo, São Paulo, Brazil., Szarf G; Universidade Federal de São Paulo, São Paulo, Brazil., Pinto IM; Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil., Fonseca FA; Universidade Federal de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Bioscience reports [Biosci Rep] 2021 Feb 26; Vol. 41 (2).
DOI:	10.1042/BSR20203413
Abstrakt:	Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass and left ventricular ejection fraction obtained by cardiac magnetic resonance imaging performed after 30 days of STEMI. This prospective study included 120 subjects with STEMI submitted to pharmacoinvasive strategy. Blood samples were collected in subjects in the first (D1) and 30th (D30) days post STEMI. The amount of CD11b+ B1 lymphocytes (cells/ml) at D1 were related to the infarcted mass (rho = 0.43; P=0.033), measured by cardiac MRI at D30. These B1 cells were associated with CD4+ T lymphocytes at D1 and D30, while B2 classic lymphocytes at day 30 were related to left ventricular ejection fraction (LVEF). Higher titers of circulating IL-4 and IL-10 were observed at D30 versus D1 (P=0.013 and P<0.001, respectively). Titers of IL-6 at D1 were associated with infarcted mass (rho = 0.41, P<0.001) and inversely related to LVEF (rho = -0.38, P<0.001). After multiple linear regression analysis, high-sensitivity troponin T and IL-6 collected at day 1 were independent predictors of infarcted mass and, at day 30, only HDL-C. Regarding LVEF, high-sensitivity troponin T and high-sensitivity C-reactive protein were independent predictors at day 1, and B2 classic lymphocytes, at day 30. In subjects with STEMI, despite early reperfusion, the amount of infarcted mass and ventricular performance were related to inflammatory responses triggered by circulating B lymphocytes. (© 2021 The Author(s).)
Databáze:	MEDLINE
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