Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry.

Autor: Immel A; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Pierini F; Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, August-Thienemann-Strasse 2, 24306, Plön, Germany., Rinne C; Institute of Pre- and Protohistoric Archaeology, Kiel University, Johanna-Mestorf-Strasse 2-6, 24118, Kiel, Germany., Meadows J; Leibniz Laboratory for AMS Dating and Isotope Research, Kiel University, Max-Eyth-Strasse 11-13, 24118, Kiel, Germany.; Centre for Baltic and Scandinavian Archaeology (ZBSA), Schloss Gottorf, 24837, Schleswig, Germany., Barquera R; Max Planck Institute for the Science of Human History, Khalaische Strasse 10, 07745, Jena, Germany., Szolek A; Applied Bioinformatics, Department for Computer Science, University of Tübingen, Sand 14, 72076, Tübingen, Germany., Susat J; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Böhme L; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Dose J; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Bonczarowska J; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Drummer C; Institute of Pre- and Protohistoric Archaeology, Kiel University, Johanna-Mestorf-Strasse 2-6, 24118, Kiel, Germany., Fuchs K; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Ellinghaus D; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Kässens JC; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Furholt M; Department of Archaeology, Conservation and History, University of Oslo, Blindernveien 11, 0371, Oslo, Norway., Kohlbacher O; Applied Bioinformatics, Department for Computer Science, University of Tübingen, Sand 14, 72076, Tübingen, Germany.; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Sand 14, 72076, Tübingen, Germany.; Institute for Translational Bioinformatics, University Hospital Tübingen, Hoppe-Seyler-Strasse 9, 72076, Tübingen, Germany.; Biomolecular Interactions, Max Planck Institute for Developmental Biology, Max-Planck-Ring 5, 72076, Tübingen, Germany., Schade-Lindig S; Landesamt für Denkmalpflege Hessen, hessenARCHÄOLOGIE, Schloss Biebrich, 65203, Wiesbaden, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Schreiber S; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany.; Department of General Internal Medicine, University Hospital Schleswig-Holstein, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Krause J; Max Planck Institute for the Science of Human History, Khalaische Strasse 10, 07745, Jena, Germany., Müller J; Institute of Pre- and Protohistoric Archaeology, Kiel University, Johanna-Mestorf-Strasse 2-6, 24118, Kiel, Germany., Lenz TL; Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, August-Thienemann-Strasse 2, 24306, Plön, Germany., Nebel A; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany., Krause-Kyora B; Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Strasse 12, 24105, Kiel, Germany. b.krause-kyora@ikmb.uni-kiel.de.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2021 Jan 25; Vol. 4 (1), pp. 113. Date of Electronic Publication: 2021 Jan 25.
DOI: 10.1038/s42003-020-01627-4
Abstrakt: The Wartberg culture (WBC, 3500-2800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe. We performed genome-wide analyses of 42 individuals who were interred in a WBC collective burial in Niedertiefenbach, Germany (3300-3200 cal. BCE). The results showed that the farming population of Niedertiefenbach carried a surprisingly large hunter-gatherer ancestry component (34-58%). This component was most likely introduced during the cultural transformation that led to the WBC. In addition, the Niedertiefenbach individuals exhibited a distinct human leukocyte antigen gene pool, possibly reflecting an immune response that was geared towards detecting viral infections.
Databáze: MEDLINE
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