Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae .

Autor: Lim KYL; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia., Mullally CA; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia., Haese EC; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia., Kibble EA; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.; School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia., McCluskey NR; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.; School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia., Mikucki EC; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia., Thai VC; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia., Stubbs KA; School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia., Sarkar-Tyson M; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia., Kahler CM; Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Jazyk: angličtina
Zdroj: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2021 Jan 21; Vol. 10 (2). Date of Electronic Publication: 2021 Jan 21.
DOI: 10.3390/antibiotics10020103
Abstrakt: While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria meningitidis , the former has become resistant to commonly available over-the-counter antibiotic treatments. It is imperative then to develop new therapies that combat current AMR isolates whilst also circumventing the pathways leading to the development of AMR. This review highlights the growing research interest in developing anti-virulence therapies (AVTs) which are directed towards inhibiting virulence factors to prevent infection. By targeting virulence factors that are not essential for gonococcal survival, it is hypothesized that this will impart a smaller selective pressure for the emergence of resistance in the pathogen and in the microbiome, thus avoiding AMR development to the anti-infective. This review summates the current basis of numerous anti-virulence strategies being explored for N. gonorrhoeae .
Databáze: MEDLINE
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