Membrane Exporters of Fluoride Ion.
| Autor: | McIlwain BC; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA; email: stockbr@umich.edu., Ruprecht MT; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA; email: stockbr@umich.edu., Stockbridge RB; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA; email: stockbr@umich.edu.; Program in Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Annual review of biochemistry [Annu Rev Biochem] 2021 Jun 20; Vol. 90, pp. 559-579. Date of Electronic Publication: 2021 Jan 25. |
| DOI: | 10.1146/annurev-biochem-071520-112507 |
| Abstrakt: | Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F - ), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years toward understanding the microbial response to cytoplasmic accumulation of F - , with a special emphasis on the structure and mechanisms of the proteins that microbes use to export fluoride: the CLC F family of F - /H + antiporters and the Fluc/FEX family of F - channels. |
| Databáze: | MEDLINE |
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