| Autor: |
Fluegel LL; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States., Hoye TR; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical reviews [Chem Rev] 2021 Feb 24; Vol. 121 (4), pp. 2413-2444. Date of Electronic Publication: 2021 Jan 25. |
| DOI: |
10.1021/acs.chemrev.0c00825 |
| Abstrakt: |
The hexadehydro-Diels-Alder (HDDA) reaction is the thermal cyclization of an alkyne and a 1,3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a variety of species to yield highly functionalized benzenoid products. In contrast to nearly all other methods of aryne generation, no other reagents are required to produce an HDDA benzyne. The versatile and customizable nature of the process has attracted much attention due not only to its synthetic potential but also because of the fundamental mechanistic insights the studies often afford. The authors have attempted to provide here a comprehensive compilation of publications appearing by mid-2020 that describe experimental results of HDDA reactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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