Shear wave elastography and transient elastography in HCV patients after direct-acting antivirals.
Autor: | Argalia G; Departement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy. giulio.argalia@gmail.com., Tarantino G; Clinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy., Ventura C; Departement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy., Campioni D; Departement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy., Tagliati C; Departement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy., Guardati P; Clinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy., Kostandini A; Clinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy., Marzioni M; Clinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti - University Hospital, Via Tronto 10, 60126, Ancona, Italy., Giuseppetti GM; Departement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy., Giovagnoni A; Departement of Radiological Sciences, A.O.U Ospedali Riuniti di Ancona, Via Conca 71, 60126, Torrette-Ancona, Italy. |
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Jazyk: | angličtina |
Zdroj: | La Radiologia medica [Radiol Med] 2021 Jun; Vol. 126 (6), pp. 894-899. Date of Electronic Publication: 2021 Jan 25. |
DOI: | 10.1007/s11547-020-01326-4 |
Abstrakt: | Purpose: To compare the ultrasound (US) and pulse shear wave elastography (pSWE, Elast PQ ® ) methods with transient elastography (TE), clinical scores and laboratory tests, during the follow-up of HCV patients receiving direct-acting antiviral drugs (DAA). Methods: Our prospective study from June 2016 to December 2017 included 22 consecutively enrolled HCV-positive patients (59.7 ± 12.3 years, 11 male) which were subjected to antiviral therapy. All patients underwent B-mode ultrasound, color-Doppler, pSWE and TE five times: before therapy (T0), at the end of therapy (post-Tx), and at 12, 24, 48 weeks post-therapy. The liver stiffness (LS) values obtained with pSWE and TE and the data coming from US assessment and clinical evaluation were compared. Results: We obtained a statistically significant reduction of LS values (kPa) measured by pSWE, between T0 (14.3 ± 9.3), post-Tx (11.8 ± 10.5), 12 weeks (7.5 ± 3.3), 24 weeks (8 ± 3.8) and 48 weeks (8.5 ± 4.6) (p = 0.02). The reduction of kPa measured by TE was not significant between T0 (14.7 ± 9.3), post-Tx (12 ± 9.5), 12 weeks (11.6 ± 7.7), 24 weeks (10.3 ± 6) and 48 weeks (10.8 ± 7.5) (p > 0.05). Multivariate baseline analysis showed significant independent association among measurement of TE stiffness with cirrhosis, type of vein hepatic flow and showed significant independent association between delta-pSWE measurement (difference between stiffness measurements at the baseline and 12 months after treatment) with staging of fibrosis (p = 0.006) and sustained virologic response after 12 weeks of treatment (SVR12, p = 0.017). Conclusion: The pSWE method has shown better ability than TE to identify a reduction in LS. Therefore, pSWE allow to evaluate stiffness reduction in HCV patient during DAA treatment follow-up, which is related to SVR12. |
Databáze: | MEDLINE |
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