| Autor: |
Lindholm V; Department of Dermatology and Allergology, Skin and Allergy Hospital, Helsinki University Hospital, Meilahdentie 2, FIN-00250 Helsinki, Finland. E-mail: vivian.lindholm@helsinki.fi., Pitkänen S, Schröder M, Hahtola S, Sahi H, Halme H, Isoherranen K |
| Jazyk: |
angličtina |
| Zdroj: |
Acta dermato-venereologica [Acta Derm Venereol] 2021 Feb 19; Vol. 101 (2), pp. adv00404. Date of Electronic Publication: 2021 Feb 19. |
| DOI: |
10.2340/00015555-3754 |
| Abstrakt: |
Previous research presents pulsed dye laser-mediated photodynamic therapy as a promising alternative to conventional red-light photodynamic therapy. In this study, 60 patients with 2 or more actinic keratoses randomly received either of these treatments on each side of the head. A physician blinded to the treatment evaluated treatment response at 6 months for each lesion, as completely, partially or not healed. Significantly lower complete clearance rates (10.3% vs 44.9%) and lesion-specific complete clearance rates were found for pulsed dye laser-mediated photodynamic therapy (47.9%) vs conventional red-light photodynamic therapy (73.4%). Significantly lower pain scores were found for pulsed dye laser-mediated photodynamic therapy, with a mean numerical rating of 2.3, compared with 4.1 for conventional red-light photodynamic therapy. The study population had a mean of 7.9 lesions, and 78% of patients had been treat-ed previously for actinic keratoses on the treatment area. To conclude, in a population with severe sun dam-age, pulsed dye laser-mediated photodynamic therapy seems less effective than conventional red-light photo-dynamic therapy. Pulsed dye laser-mediated photodynamic therapy may still be a treatment option for patients who are not compliant with conventional red-light photodynamic therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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