Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research.

Autor: Ng KP; Department of Neurology National Neuroscience Institute Singapore Singapore.; Duke-NUS Medical School Singapore Singapore.; Lee Kong Chian School of Medicine - Imperial College London Nanyang Technological University Singapore Singapore., Chiew HJ; Department of Neurology National Neuroscience Institute Singapore Singapore., Hameed S; Department of Neurology National Neuroscience Institute Singapore Singapore.; Duke-NUS Medical School Singapore Singapore.; Lee Kong Chian School of Medicine - Imperial College London Nanyang Technological University Singapore Singapore., Ting SKS; Department of Neurology National Neuroscience Institute Singapore Singapore.; Duke-NUS Medical School Singapore Singapore.; Lee Kong Chian School of Medicine - Imperial College London Nanyang Technological University Singapore Singapore., Ng A; Department of Neurology National Neuroscience Institute Singapore Singapore.; Duke-NUS Medical School Singapore Singapore.; Lee Kong Chian School of Medicine - Imperial College London Nanyang Technological University Singapore Singapore., Soo SA; Department of Neurology National Neuroscience Institute Singapore Singapore., Wong BYX; Department of Neurology National Neuroscience Institute Singapore Singapore., Lim L; Department of Neurology National Neuroscience Institute Singapore Singapore., Yong ACW; Department of Neurology National Neuroscience Institute Singapore Singapore., Mok VCT; Gerald Choa Neuroscience Centre Lui Che Woo Institute of Innovative Medicine Department of Medicine and Therapeutics Prince of Wales Hospital Faculty of Medicine The Chinese University of Hong Kong Shatin New Territories Hong Kong SAR China., Rosa-Neto P; Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Alzheimer's Disease Research Unit Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics McGill University Montreal Canada., Dominguez J; St. Luke's Medical Center Institute for Neurosciences Metro Manila Philippines., Kim S; Department of Neurology Seoul National University College of Medicine and Clinical Neuroscience Center of Seoul National University Bundang Hospital Seongnam-si Korea., Hsiung GYR; Department of Medicine University of British Columbia Vancouver British Columbia Canada., Ikeda M; Department of Psychiatry Graduate School of Medicine, Osaka University Osaka Japan., Miller BL; Memory and Aging Center Department of Neurology University of California San Francisco San Francisco California USA., Gauthier S; Translational Neuroimaging Laboratory McGill University Research Centre for Studies in Aging Alzheimer's Disease Research Unit Douglas Research Institute Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics McGill University Montreal Canada., Kandiah N; Department of Neurology National Neuroscience Institute Singapore Singapore.; Duke-NUS Medical School Singapore Singapore.; Lee Kong Chian School of Medicine - Imperial College London Nanyang Technological University Singapore Singapore.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2021 Jan 15; Vol. 6 (1), pp. e12085. Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2020).
DOI: 10.1002/trc2.12085
Abstrakt: The COVID-19 pandemic has caused tremendous suffering for patients with dementia and their caregivers. We conducted a survey to study the impact of the pandemic on patients with mild frontotemporal dementia (FTD). Our preliminary findings demonstrate that patients with FTD have significant worsening in behavior and social cognition, as well as suffer greater negative consequences from disruption to health-care services compared to patients with AD. The reduced ability to cope with sudden changes to social environments places patients with FTD at increased vulnerability to COVID-19 infection as well as to poorer clinical and social outcomes. Caregivers of FTD patients also demonstrate high burden during crisis situations. A proportion of patients with FTD benefitted from use of web-based interactive platforms. In this article, we outline the priority areas for research as well as a roadmap for future collaborative research to ensure greatest benefit for patients with FTD and their caregivers.
Competing Interests: The authors report no conflicts of interest.
(© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.)
Databáze: MEDLINE
Externí odkaz: