Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer's disease except for the putamen.

Autor: Zammit MD; University of Wisconsin-Madison Waisman Center Madison Wisconsin USA., Laymon CM; Department of Radiology, University of Pittsburgh Pittsburgh Pennsylvania USA.; Department of Bioengineering, University of Pittsburgh Pittsburgh Pennsylvania USA., Tudorascu DL; Department of Psychiatry, University of Pittsburgh Pittsburgh Pennsylvania USA., Hartley SL; University of Wisconsin-Madison Waisman Center Madison Wisconsin USA., Piro-Gambetti B; University of Wisconsin-Madison Waisman Center Madison Wisconsin USA., Johnson SC; University of Wisconsin-Madison Alzheimer's Disease Research Center Madison Wisconsin USA., Stone CK; Department of Medicine, University of Wisconsin-Madison Madison Wisconsin USA., Mathis CA; Department of Radiology, University of Pittsburgh Pittsburgh Pennsylvania USA., Zaman SH; University of Cambridge Intellectual Disability Research Group Cambridge UK., Klunk WE; Department of Psychiatry, University of Pittsburgh Pittsburgh Pennsylvania USA., Handen BL; Department of Psychiatry, University of Pittsburgh Pittsburgh Pennsylvania USA., Cohen AD; Department of Psychiatry, University of Pittsburgh Pittsburgh Pennsylvania USA., Christian BT; University of Wisconsin-Madison Waisman Center Madison Wisconsin USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2021 Jan 13; Vol. 12 (1), pp. e12138. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2020).
DOI: 10.1002/dad2.12138
Abstrakt: Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated.
Methods: Adults with DS (N = 90; mean age [standard deviation] = 38.0 [8.30] years) underwent [C-11]Pittsburgh compound B (PiB) and [F-18]fluorodeoxyglucose (FDG) positron emission tomography scans. Associations among amyloid beta (Aβ), FDG, and measures of cognition were explored. Interregional FDG metabolic connectivity was assessed to compare cognitively stable DS and mild cognitive impairment/AD (MCI-DS/AD).
Results: Negative associations between Aβ and FDG were evident in regions affected in sporadic AD. A positive association was observed in the putamen, which is the brain region showing the earliest increases in Aβ deposition. Both Aβ and FDG were associated with measures of cognition, and metabolic connectivity distinguished cases of MCI-DS/AD from cognitively stable DS.
Discussion: Associations among Aβ, FDG, and cognition reveal that neurodegeneration in DS resembles sporadic AD with the exception of the putamen, highlighting the usefulness of FDG in monitoring neurodegeneration in DS.
Competing Interests: GE Healthcare holds a license agreement with the University of Pittsburgh based on the technology described in this manuscript. Dr. Klunk is a co‐inventor of PiB and, as such, has a financial interest in this license agreement. GE Healthcare provided no grant support for this study and had no role in the design or interpretation of results or preparation of this manuscript. All other authors have no conflicts of interest with this work and had full access to all of the data in the study, and take responsibility for the integrity of the data and the accuracy of the data analysis.
(© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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