Cystatin C and Seminal Parameter Evaluation in Patients with End-Stage Renal Disease.
| Autor: | Silva GP; Urologist of the University of Brasilia, Brasilia., Grangeiro VPX; Academic of the Medical Course of the School of Medical Sciences, João Pessoa., de Oliveira CFD; Academic of the Medical Course of the School of Medical Sciences, João Pessoa., Neto FL; Academic of the Medicine Course Federal University of Pará, Belém, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Current urology [Curr Urol] 2020 Dec; Vol. 14 (4), pp. 178-182. Date of Electronic Publication: 2020 Dec 18. |
| DOI: | 10.1159/000499241 |
| Abstrakt: | Objective: We aimed to investigate the possible relationship between seminal parameters and cystatin C seminal levels in an infertility evaluation of chronic hemodialysis patients. Materials and Methods: This was a cross-sectional study, aged 18-60 years, in a group of 60 men undergoing hemodialysis (case) for more than 6 months, and a group of 15 healthy men (control) without clinical or laboratory signs of genitourinary tract infection. We performed a spermogram, hormonal profile, and assessment of leukocytes and cystatin levels in the semen. Results: The ages in the case and control were similar (p = 0.060). The seminal cystatin was significantly different between the case group and control group (41.16 ± 26.59 vs. 79.00 ± 05.68 mg/l, respectively, p < 0.001) and between normospermia and oligospermia (83.50 ± 02.40 vs. 30.34 ± 02.52 mg/l, respectively, p < 0.001). The mean seminal cystatin levels identified by the degrees of oligospermia (severe, moderate, and slim) were similar to each other (p > 0.05) and significantly different (p < 0.05) in relation to normospermia in the case group. The seminal cystatin levels positively correlated (p < 0.05) with sperm motility and sperm density. Conclusion: Seminal cystatin levels are associated with the numerical and motility changes evidenced in the spermogram and may be of help in the initial evaluation of clinical suspicion of sub-fertility and infertility. (Copyright © 2020 by S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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