Rifampicin-Resistant Tuberculosis in a Toddler: A Report of a Rare Paediatric Case in Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

Autor: Edward SS; Department of Paediatrics, Paediatric Gastroenterology/Nutrition Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria., Akande JI; Department of Paediatrics, Paediatric Gastroenterology/Nutrition Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria., Obiajunwa PO; Department of Paediatrics, Paediatric Pulmonology Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Jazyk: angličtina
Zdroj: Nigerian medical journal : journal of the Nigeria Medical Association [Niger Med J] 2020 Sep-Oct; Vol. 61 (5), pp. 281-283. Date of Electronic Publication: 2020 Oct 13.
DOI: 10.4103/nmj.NMJ_210_20
Abstrakt: The emergence of resistant strains of mycobacterium tuberculosis (TB) to antituberculous drugs has compounded the management of the chronic infection. More than 90% of rifampicin (RIF)-resistant isolates are also isoniazid resistant; hence, rifampicin resistance (RR) is a surrogate marker for multidrug resistant TB (MDR-TB). Although there are limited reports of pediatric RR/MDR-TB in Nigeria, there had not been similar report in our hospital until now. A 2-year-old girl was admitted with 2-month history of fever, cough with dyspnea, and progressive weight loss. There was no known contact with adult who had chronic cough; the toddler and her parents have not been treated for TB in the past. Her chest X-ray showed nodular opacities, while gastric washout for GeneXpert MTB/RIF confirmed RIF-resistant TB. The parents declined screening for TB despite counseling. The patient was subsequently referred to a specialized center for the management of drug-resistant TB, but the parents failed to go for the treatment. Young children are at risk of developing TB disease and MDR/RR-TB, which is more complex to manage than drug-susceptible TB due to longer treatment duration, increased toxicity, as well as poor parental compliance to the demand of treatment.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2020 Nigerian Medical Journal.)
Databáze: MEDLINE
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