A Nationwide, Multicentric Case-Control Study on Vitiligo (MEDEC-V) to Elicit the Magnitude and Correlates.

Autor: Sarma N; Department of Dermatology, Dr B C Roy Post Graduate Institute of Pediatric Science, Kolkata, West Bengal, India., Chakraborty S; Department of RG Kar Medical College, Kolkata, West Bengal, India., Poojary S; K J Somaiya Medical College, Mumbai, Maharashtra, India., Shashi Kumar BM; Mandya Institute of Medical Sciences, Mandya, Karnataka, India., Gupta LK; RNT Medical College, Udaipur, Rajasthan, India., Budamakuntla L; Victoria/Bowring Hospitals, Bangalore Medical College and RI, Karnataka, India., Kumrah L; CIHSR, 4TH MILE, Dimapur, Nagaland, India., Das S; NRS Medical College, Kolkata, West Bengal, India., Ovhal AG; Government Medical College, Latur, Maharashtra, India., Mandal NK; Malda Medical College, Malda, West Bengal, India., Mukherjee S; Department of Community Medicine, Calcutta National Medical College, Kolkata, India., Anoop TV; Pariyaram Medical College, Kannur, Kerala, India., Thakur BK; NEIGRIHMS, Shillong, Meghalaya, India., Eswari L; Bangalore Medical College and RI, Bangalore, Karnataka, India., Samson JF; Dr. Somervell Memorial CSI Medical College, Karakonam, Trivandrum, Kerala, India., Patel KB; GMERS Medical College, Sola, Ahmedabad, Gujarat, India., Rajagopalan R; Perundurai Medical College Hospital, Erode, Tamil Nadu, India., Gupta S; MM Institute of Medical Sciences and Research, Mullana Ambala, Haryana, India., Kaur T; Government Medical College, Amritsar, Punjab, India.
Jazyk: angličtina
Zdroj: Indian journal of dermatology [Indian J Dermatol] 2020 Nov-Dec; Vol. 65 (6), pp. 473-482.
DOI: 10.4103/ijd.IJD_822_19
Abstrakt: Background: Vitiligo is an acquired, idiopathic, and common depigmentation disorder. The values of various epidemiologic parameters are often doubtful due to the methodological weaknesses of the studies.
Aims: To elicit the magnitude of various epidemiological parameters and important correlates of vitiligo.
Materials and Methods: Every vitiligo patient attending the outpatient department of medical colleges spread over most of the Indian states were examined over a period of 1 year. Various epidemiological and clinical variables were examined and compared with age and sex-matched controls (registered in the Clinical Trial Registry of India CTRI/2017/06/008854).
Results: A total of 4,43,275 patients were assessed in 30 medical colleges from 21 Indian states. Institutional prevalence of vitiligo was 0.89% (0.86% in males and 0.93% in females, P < 0.001). The mean age at presentation and mean age at onset were 30.12 ± 17.97 years and 25.14 ± 7.48 years, respectively. Head-neck was the most common primary site ( n = 1648, 41.6%) and most commonly affected site ( n = 2186, 55.17%). Most cases had nonsegmental vitiligo ( n = 2690, 67.89%). The disease started before 20 years of age in more than 46% of cases. About 77% of all cases had signs of instability during the last 1 year. The family history, consanguinity, hypothyroid disorders, and depressed mood were significantly ( P < 0.001) higher among the cases. First, second, and third-degree family members were affected in 269 (60.04%), 111 (24.78%), and 68 (15.18%) cases, respectively. Work-related exposure to chemicals was significantly higher among cases ( P < 0.008). Obesity was less common among vitiligo cases [ P < 0.001, odds ratio (OR) 0.78, 95% confidence interval (CI): 0.71-0.86].
Conclusion: This is one of the largest studies done on vitiligo in India. The prevalence of vitiligo was found to be 0.89% among hospital attendees. Prevalence of vitiligo was higher among females than in males and prevalence of family history, consanguinity, hypothyroid disorders were higher in vitiligo than among controls.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2020 Indian Journal of Dermatology.)
Databáze: MEDLINE
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