Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial.

Autor: Zurbau A; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Toronto, ON, Canada., Smircic Duvnjak L; Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia., Magas S; Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Zagreb, Croatia., Jovanovski E; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada., Miocic J; Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Zagreb, Croatia., Jenkins AL; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada., Jenkins DJA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.; Departments of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Josse RG; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.; Departments of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Leiter LA; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.; Departments of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Sievenpiper JL; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.; Departments of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Vuksan V; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. v.vuksan@utoronto.ca.; Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada. v.vuksan@utoronto.ca.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. v.vuksan@utoronto.ca.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada. v.vuksan@utoronto.ca.; Departments of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. v.vuksan@utoronto.ca.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2021 Sep; Vol. 60 (6), pp. 3071-3083. Date of Electronic Publication: 2021 Jan 24.
DOI: 10.1007/s00394-020-02434-7
Abstrakt: Purpose: Viscous dietary fiber, functional seeds and ginseng roots have individually been proposed for the management of diabetes. We explored whether their co-administration would improve glycemic control in type 2 diabetes beyond conventional therapy.
Methods: In a randomized, double-blind, controlled trial conducted at two academic centers (Toronto, Canada and Zagreb, Croatia), individuals with type 2 diabetes were assigned to either an active intervention (10 g viscous fiber, 60 g white chia seeds, 1.5 g American and 0.75 g Korean red ginseng extracts), or energy and fiber-matched control (53 g oat bran, 25 g inulin, 25 g maltodextrose and 2.25 g wheat bran) intervention for 24 weeks, while on conventional standard of care. The prespecified primary endpoint was end difference at week 24 in HbA1c, following an intent-to-treat analysis adjusted for center and baseline.
Results: Between January 2016 and April 2018, 104 participants (60M:44F; mean ± SEM age 59 ± 0.8 years; BMI 29.0 ± 0.4 kg/m 2 ; HbA1c 7.0 ± 0.6%) managed with antihyperglycemic agent(s) (n = 98) or lifestyle (n = 6), were randomized (n = 52 test; n = 52 control). At week 24, HbA1c levels were 0.27 ± 0.1% lower on test compared to control (p = 0.03). There was a tendency towards an interaction by baseline HbA1c (p = 0.07), in which a greater reduction was seen in participants with baseline HbA1c > 7% vs ≤ 7% (- 0.56 ± 0.2% vs 0.03 ± 0.2%). Diet and body weight remained unchanged. The interventions were well tolerated with no related adverse events and with high retention rate of 84%.
Conclusions: Co-administration of selected dietary and herbal therapies was well-tolerated and may provide greater glycemic control as add-on therapy in type 2 diabetes. Registration: Clinicaltrials.gov NCT02553382 (registered on September 17, 2015).
(© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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