Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children.

Autor: Knihtilä HM; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Stubbs BJ; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Carey VJ; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Laranjo N; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Chu SH; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Kelly RS; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Zeiger RS; Departments of Allergy and Research and Evaluation, Kaiser Permanente Southern California Region, San Diego and Pasadena, Calif., Bacharier LB; Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo., O'Connor GT; Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Mass., Lasky-Su J; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Weiss ST; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address: scott.weiss@channing.harvard.edu., Litonjua AA; Division of Pediatric Pulmonary Medicine, Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jul; Vol. 148 (1), pp. 110-119.e9. Date of Electronic Publication: 2021 Jan 22.
DOI: 10.1016/j.jaci.2020.12.647
Abstrakt: Background: Lung function impairment in early life often persists into adulthood. Therefore, identifying risk factors for low childhood lung function is crucial.
Objective: We examined the effect of 25-hydroxyvitamin D (25[OH]D) level and childhood asthma phenotype on childhood lung function in the Vitamin D Antenatal Asthma Reduction Trial (VDAART).
Methods: The 25(OH)D level was measured at set time points in mothers during pregnancy and in children during early life. On the basis of parental reports, children were categorized into 3 clinical phenotypes: asymptomatic/infrequent wheeze, early transient wheeze, and asthma at age 6 years. Lung function was assessed with impulse oscillometry at ages 4, 5, and 6 years and with spirometry at ages 5 and 6 years.
Results: A total of 570 mother-child pairs were included in this post hoc analysis. Mean gestational 25(OH)D-level quartiles were negatively associated with child respiratory resistance at 5 Hz (R5) from age 4 to 6 years (β, -0.021 kPa/L/s; 95% CI, -0.035 to -0.007; P = .003) and positively associated with FEV 1 (β, 0.018 L; 95% CI, 0.005-0.031; P = .008) and forced vital capacity (β, 0.022 L; 95% CI, 0.009-0.036; P = .002) from age 5 to 6 years. Children with asthma at age 6 years had lower lung function from age 4 to 6 years than the asymptomatic/infrequent wheeze group (β, 0.065 kPa/L/s; 95% CI, 0.028 to 0.102; P < .001 for R5 and β, -0.063 L; 95% CI, -0.099 to -0.028; P < .001 for FEV 1 ).
Conclusions: Low gestational 25(OH)D level and childhood asthma are important risk factors for decreased lung function in early childhood.
(Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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