Short-Term Western Diet Intake Promotes IL-23‒Mediated Skin and Joint Inflammation Accompanied by Changes to the Gut Microbiota in Mice.

Autor:	Shi Z; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA; Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Wu X; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA., Santos Rocha C; Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Sacramento, California, USA., Rolston M; Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Sacramento, California, USA., Garcia-Melchor E; Institute of Infection, Immunity & Inflammation, College of Medicine, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom., Huynh M; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA., Nguyen M; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA., Law T; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA., Haas KN; Biology Department, University of Massachusetts Amherst, Amherst, Massachusetts, USA., Yamada D; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA., Millar NL; Institute of Infection, Immunity & Inflammation, College of Medicine, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom., Wan YY; Department of Medical Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, California, USA., Dandekar S; Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Sacramento, California, USA., Hwang ST; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA. Electronic address: sthwang@ucdavis.edu.
Jazyk:	angličtina
Zdroj:	The Journal of investigative dermatology [J Invest Dermatol] 2021 Jul; Vol. 141 (7), pp. 1780-1791. Date of Electronic Publication: 2021 Jan 22.
DOI:	10.1016/j.jid.2020.11.032
Abstrakt:	We previously showed that exposure to a high-sugar and moderate-fat diet (i.e., Western diet [WD]) in mice induces appreciable skin inflammation and enhances the susceptibility to imiquimod-induced psoriasiform dermatitis, suggesting that dietary components may render the skin susceptible to psoriatic inflammation. In this study, utilizing an IL-23 minicircle-based model with features of both psoriasiform dermatitis and psoriatic arthritis, we showed that intake of WD for 10 weeks predisposed mice not only to skin but also to joint inflammation. Both WD-induced skin and joint injuries were associated with an expansion of IL-17A‒producing γδ T cells and increased expression of T helper type 17 cytokines. After IL-23 minicircle delivery, WD-fed mice had reduced microbial diversity and pronounced dysbiosis. Treatment with broad-spectrum antibiotics suppressed IL-23‒mediated skin and joint inflammation in the WD-fed mice. Strikingly, reduced skin and joint inflammation with a partial reversion of the gut microbiota were noted when mice switched from a WD to a standard diet after IL-23 minicircle delivery. These findings reveal that a short-term WD intake‒induced dysbiosis is accompanied by enhanced psoriasis-like skin and joint inflammation. Modifications toward a healthier dietary pattern should be considered in patients with psoriatic skin and/or joint disease. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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