Effects of the aqueous extract of Phyllanthus niruri Linn during pregnancy and lactation on neurobehavioral parameters of rats' offspring.

Autor: da Costa Alves M; Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil. Electronic address: alvesm.c.50@gmail.com., Pereira DE; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil; Federal University of Paraiba, University City, 58051-900, João Pessoa, Paraíba State, Brazil. Electronic address: diegoelias.ufcg@gmail.com., de Cássia de Araújo Bidô R; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil; Federal University of Paraiba, University City, 58051-900, João Pessoa, Paraíba State, Brazil. Electronic address: rita_decassia_ita@hotmail.com., Rufino Freitas JC; Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil; Chemistry Department, Rural Federal University of Pernambuco, University City, 50740-540, Recife, Pernambuco State, Brazil. Electronic address: julianocrf@gmail.com., Fernandes Dos Santos CP; Chemistry Department, Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil. Electronic address: santosclaudia0412@gmail.com., Barbosa Soares JK; Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil; Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Campina Grande, Sítio Olho d'água da Bica, 58175-000, Cuité, Paraíba State, Brazil; Federal University of Paraiba, University City, 58051-900, João Pessoa, Paraíba State, Brazil. Electronic address: julianakessia2@gmail.com.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 24; Vol. 270, pp. 113862. Date of Electronic Publication: 2021 Jan 21.
DOI: 10.1016/j.jep.2021.113862
Abstrakt: Ethnopharmacological Relevance: Phyllanthus niruri L. (Phyllanthaceae) is a plant used in traditional medicine, mainly to treat kidney stones. However, the effects of maternal exposure to P. niruri remain poorly explored.
Aim of the Study: The objective of this study was to investigate the effects of administration of aqueous extract of P. niruri (AEPN) during pregnancy and lactation, in maternal toxicity, reflex maturation, and offspring memory.
Materials and Methods: Pregnant rats were divided into three groups (n = 8/group): Control (vehicle), AEPN 75, and AEPN 150 (each respectively treated with P. niruri at a dose of 75 and 150 mg/kg/day). The animals were treated via intragastric gavage during pregnancy and lactation. Weight gain, feed intake, and reproductive performance were analyzed in the mothers. In the offspring, the following tests were performed: Neonatal Reflex Ontogeny, Open Field Habituation Test and the Object Recognition Test in adulthood.
Results: Maternal exposure to AEPN did not influence weight gain, feed intake, or reproductive parameters. In the offspring, anticipation of reflex ontogenesis (time of completion) was observed (p < 0.05). During adulthood, the AEPN groups presented decreases in exploratory activity upon their second exposure to the Open Field Habituation Test (in a dose-dependent manner) (p < 0.05). In the Object Recognition Test, administration of the extract at 75 and 150 mg/kg induced significant dose-dependent improvements in short and long-term memory (p < 0.05).
Conclusion: Administration of the AEPN accelerated the reflex maturation in neonates, and improved offspring memory while inducing no maternal or neonatal toxicity.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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