SARS-CoV-2 seroconversion among 4040 Egyptian healthcare workers in 12 resource-limited healthcare facilities: A prospective cohort study.

Autor:	Mostafa A; Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: aya.kamaleldin@med.asu.edu.eg., Kandil S; Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt., El-Sayed MH; Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Clinical Research Center (MASRI-CRC), Faculty of Medicine, Ain Shams University, Cairo, Egypt., Girgis S; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Hafez H; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Yosef M; Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Saber S; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ezzelarab H; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ramadan M; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Algohary E; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Ain Shams University Specialized Hospitals, Egypt., Fahmy G; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Ain Shams University Specialized Hospitals, Egypt., Afifi I; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Hassan F; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Elsayed S; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Reda A; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Fattuh D; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Mahmoud A; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Mansour A; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Sabry M; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Habeb P; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt., Ebeid FS; Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Clinical Research Center (MASRI-CRC), Faculty of Medicine, Ain Shams University, Cairo, Egypt., Elanwar A; Ain Shams University Specialized Hospitals, Egypt; Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Saleh A; Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Mansour O; Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Omar A; Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt., El-Meteini M; Department of Hepatobiliary Surgery & Liver Transplantation, Ain Shams Center for Organ Transplantation (ASCOT), Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Mar; Vol. 104, pp. 534-542. Date of Electronic Publication: 2021 Jan 20.
DOI:	10.1016/j.ijid.2021.01.037
Abstrakt:	Background: We examined Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) seroconversion incidence and risk factors 21 days after baseline screening among healthcare workers (HCWs) in a resource-limited setting. Methods: A prospective cohort study of 4040 HCWs took place at 12 university healthcare facilities in Cairo, Egypt; April-June 2020. Follow-up exposure and clinical data were collected through online survey. SARS-CoV-2 testing was done using rapid IgM and IgG serological tests and reverse transcriptase-polymerase chain reaction (RT-PCR) for those with positive serology. Cox proportional hazards modelling was used to estimate adjusted hazard ratios (HR) of seroconversion. Results: 3870/4040 (95.8%) HCWs tested negative for IgM, IgG and PCR at baseline; 2282 (59.0%) returned for 21-day follow-up. Seroconversion incidence (positive IgM and/or IgG) was 100/2282 (4.4%, 95% CI:3.6-5.3), majority asymptomatic (64.0%); daily hazard of 0.21% (95% CI:0.17-0.25)/48 746 person-days of follow-up. Seroconversion was: 4.0% (64/1596; 95% CI:3.1-5.1) among asymptomatic; 5.3% (36/686; 95% CI:3.7-7.2) among symptomatic HCWs. Seroconversion was independently associated with older age; lower education; contact with a confirmed case >15 min; chronic kidney disease; pregnancy; change/loss of smell; and negatively associated with workplace contact. Conclusions: Most seroconversions were asymptomatic, emphasizing need for regular universal testing. Seropositivity was three-fold that observed at baseline. Cumulative infections increased nationally by a similar rate, suggesting HCW infections reflect community not nosocomial transmission. (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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