Ten-year trends in epidemiology and outcomes of pediatric kidney replacement therapy in Europe: data from the ESPN/ERA-EDTA Registry.

Autor: Bonthuis M; ESPN/ERA-EDTA Registry, Amsterdam UMC, University of Amsterdam, Department of Medical Informatics, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, The Netherlands. m.bonthuis@amsterdamumc.nl., Vidal E; Division of Pediatrics, Department of Medicine, University of Udine, Udine, Italy., Bjerre A; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Aydoğ Ö; Department of Pediatric Nephrology, 19 Mayis University Medical School, Samsun, Turkey., Baiko S; Department of Pediatrics, Belarusian State Medical University, Minsk, Belarus., Garneata L; Department of Internal Medicine and Nephrology 'Dr Carol Davila' Teaching Hospital of Nephrology, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania., Guzzo I; Nephrology and Dialysis Unit, Pediatric Subspecialties Department, Institute for Scientific Research, Bambino Gesù Children's Hospital, Rome, Italy., Heaf JG; Department of Medicine, Zealand University Hospital, Roskilde, Denmark., Jahnukainen T; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Lilien M; Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands., Mallett T; Department of Paediatric Nephrology, Royal Belfast Hospital for Sick Children, Belfast, UK.; Department of Paediatric Nephrology, Royal Bristol Hospital for Children, Bristol, UK., Mirescu G; Department of Nephrology and Internal Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Department of Nephrology, 'Dr. Carol Davila' Teaching Hospital of Nephrology, Bucharest, Romania., Mochanova EA; Department of Kidney Transplantation, Russian Children's Federal Clinical Hospital of Pirogov Russian National Research Medical University, Moscow, Russia., Nüsken E; Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Rascher K; QiN-Group, Department of Medicine II, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Roussinov D; SBAL Pediatric Diseases, Nephrology and Hemodialysis Clinic, Department of Pediatrics, Medical University of Sofia, 1606, Sofia, Bulgaria., Szczepanska M; Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland., Tsimaratos M; Department of Multidisciplinary Pediatrics, Pediatric Nephrology Unit, Assistance Publique des Hôpitaux de Marseille, Marseille, France., Varvara A; Nephrology Unit, Kyriakou Children's Hospital, Athens, Greece., Verrina E; Dialysis Unit, Department of Pediatrics, IRCCS Giannina Gaslini, Genoa, Italy., Veselinović B; Nephrology Department, University Children's Hospital, Belgrade, Serbia., Jager KJ; ESPN/ERA-EDTA Registry, Amsterdam UMC, University of Amsterdam, Department of Medical Informatics, Amsterdam Public Health Research Institute, Meibergdreef 9, Amsterdam, The Netherlands., Harambat J; Department of Pediatrics, Bordeaux University Hospital, Bordeaux Population Health Research Center UMR 1219, University of Bordeaux, Bordeaux, France.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2021 Aug; Vol. 36 (8), pp. 2337-2348. Date of Electronic Publication: 2021 Jan 22.
DOI: 10.1007/s00467-021-04928-w
Abstrakt: Background: For 10 consecutive years, the ESPN/ERA-EDTA Registry has included data on children with stage 5 chronic kidney disease (CKD 5) receiving kidney replacement therapy (KRT) in Europe. We examined trends in incidence and prevalence of KRT and patient survival.
Methods: We included all children aged <15 years starting KRT 2007-2016 in 22 European countries participating in the ESPN/ERA-EDTA Registry since 2007. General population statistics were derived from Eurostat. Incidence and prevalence were expressed per million age-related population (pmarp) and time trends studied with JoinPoint regression. We analyzed survival trends using Cox regression.
Results: Incidence of children commencing KRT <15 years remained stable over the study period, varying between 5.5 and 6.6 pmarp. Incidence by treatment modality was unchanged over time: 2.0 for hemodialysis (HD) and peritoneal dialysis (PD) and 1.0 for transplantation. Prevalence increased in all age categories and overall rose 2% annually from 26.4 pmarp in 2007 to 32.1 pmarp in 2016. Kidney transplantation prevalence increased 5.1% annually 2007-2009, followed by 1.5% increase/year until 2016. Prevalence of PD steadily increased 1.4% per year over the entire period, and HD prevalence started increasing 6.1% per year from 2011 onwards. Five-year unadjusted patient survival on KRT was around 94% and similar for those initiating KRT 2007-2009 or 2010-2012 (adjusted HR: 0.98, 95% CI:0.71-1.35).
Conclusions: We found a stable incidence and increasing prevalence of European children on KRT 2007-2016. Five-year patient survival was good and was unchanged over time. These data can inform patients and healthcare providers and aid health policy makers on future resource planning of pediatric KRT in Europe.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje